Pseudomonas mandelii JR-1, OU5_RS00385

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0009086 methionine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF56507
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0031419 cobalamin binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd02069
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008705 methionine synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF56507
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0042558 pteridine-containing compound metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00809
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008270 zinc ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000381
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0046872 metal ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02310
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0044237 cellular metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.20.20.20
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pman00670 One carbon pool by folate 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc folate transformations II InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc folate transformations I InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG pman01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pman01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pman01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pman00270 Cysteine and methionine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pman00450 Selenocompound metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc L-methionine biosynthesis IV (archaea) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PIRSF PIRSF000381 Met_synth_MetH IPR011822 Cobalamin-dependent methionine synthase 4 1205 0.0
FunFam G3DSA:3.20.20.330:FF:000001 Methionine synthase - - 5 341 0.0
Gene3D G3DSA:3.40.50.280 - - - 746 898 7.4E-57
Coils Coil Coil - - 1234 1236 -
FunFam G3DSA:1.10.1240.10:FF:000001 Methionine synthase - - 647 741 2.2E-44
Pfam PF02574 Homocysteine S-methyltransferase IPR003726 Homocysteine-binding domain 20 328 3.5E-77
SUPERFAMILY SSF47644 Methionine synthase domain IPR036594 Methionine synthase domain 653 739 6.41E-27
Gene3D G3DSA:1.10.1240.10 Methionine synthase domain IPR036594 Methionine synthase domain 646 739 4.4E-37
CDD cd00740 MeTr - - 359 615 1.67601E-124
Gene3D G3DSA:3.20.20.330 - IPR036589 Homocysteine-binding domain superfamily 5 341 1.2E-121
CDD cd02069 methionine_synthase_B12_BD IPR033706 Methionine synthase, B12-binding domain 660 874 1.3831E-124
Pfam PF00809 Pterin binding enzyme IPR000489 Pterin-binding domain 363 601 9.3E-57
Pfam PF02607 B12 binding domain IPR003759 Cobalamin (vitamin B12)-binding module, cap domain 661 733 1.8E-23
Gene3D G3DSA:3.10.196.10 - IPR037010 Vitamin B12-dependent methionine synthase, activation domain superfamily 910 1234 0.0
SUPERFAMILY SSF51717 Dihydropteroate synthetase-like IPR011005 Dihydropteroate synthase-like 359 632 2.35E-88
SMART SM01018 B12_binding_2_2 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain 658 741 1.8E-40
Pfam PF02310 B12 binding domain IPR006158 Cobalamin (vitamin B12)-binding domain 750 843 4.8E-18
Gene3D G3DSA:3.20.20.20 - IPR011005 Dihydropteroate synthase-like 349 645 0.0
FunFam G3DSA:3.20.20.20:FF:000002 Methionine synthase - - 349 645 0.0
Pfam PF02965 Vitamin B12 dependent methionine synthase, activation domain IPR004223 Vitamin B12-dependent methionine synthase, activation domain 941 1218 4.0E-120
SUPERFAMILY SSF82282 Homocysteine S-methyltransferase IPR036589 Homocysteine-binding domain superfamily 11 402 8.11E-116
FunFam G3DSA:3.40.50.280:FF:000001 Methionine synthase - - 746 898 6.1E-78
SUPERFAMILY SSF52242 Cobalamin (vitamin B12)-binding domain IPR036724 Cobalamin-binding domain superfamily 744 896 2.09E-44
Gene3D G3DSA:1.10.288.10 - - - 940 1097 0.0
SUPERFAMILY SSF56507 Methionine synthase activation domain-like IPR037010 Vitamin B12-dependent methionine synthase, activation domain superfamily 905 1235 4.45E-122
NCBIfam TIGR02082 JCVI: methionine synthase IPR011822 Cobalamin-dependent methionine synthase 15 1202 0.0
PANTHER PTHR45833 METHIONINE SYNTHASE - - 9 1234 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.