This analysis is based on the study "The association of virulence factors with genomic islands" (Ho Sui, Fedynak, Hsiao, Langille, and Brinkman (2009), PLoS ONE).

BLAST similarity searches were performed against the deduced proteomes of 1292 pathogenic and 1490 non-pathogenic sequenced prokaryotic genomes downloaded from the National Center for Biotechnology Information FTP site in December 2014. An e-value cut-off of 10-7 was used to exclude distant homologs. Pathogen or non-pathogen status for each genome was obtained through the NCBI Complete Microbial Genomes webpage (Haft et al. 2005) and then manually curated to ensure data quality and completeness.

The current categories for 'Status' are:

1) Pathogen: Protein only had BLAST hits to proteins in pathogenic strains.

2) Non-Pathogen: Protein only had BLAST hits to proteins in non-pathogenic strains.

3) Common: The protein had BLAST hits to proteins in both pathogenic and non-pathogenic strains.

The 'Virulence Evidence?' column indicates whether any evidence is available in the database for this gene being virulence associated (i.e. VFDB, Victors Virulence Factors, curation by Pseudomonas Genome Database, etc.).

Important note on this analysis: The list of genes defined as being pathogen-associated will change as more genomes are sequenced. This analysis will be updated at a later time in order to reflect this.