Pseudomonas sp. UW4, PputUW4_03595 (ligA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0003911 DNA ligase (NAD+) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00532
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006260 DNA replication
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF03120
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006281 DNA repair
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF03120
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003677 DNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00278
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Pathways

Database Xref Pathway Version Evidence PMID
KEGG ppuu03030 DNA replication 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG ppuu03430 Mismatch repair 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG ppuu03420 Nucleotide excision repair 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG ppuu03410 Base excision repair 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:6.20.10.30 - - - 398 448 3.1E-14
SUPERFAMILY SSF47781 RuvA domain 2-like IPR010994 RuvA domain 2-like 611 695 1.27E-11
Gene3D G3DSA:3.40.50.10190 BRCT domain IPR036420 BRCT domain superfamily 703 784 1.1E-22
FunFam G3DSA:3.30.470.30:FF:000001 DNA ligase - - 65 322 9.4E-108
Pfam PF03119 NAD-dependent DNA ligase C4 zinc finger domain IPR004149 Zinc-finger, NAD-dependent DNA ligase C4-type 414 453 9.7E-11
Gene3D G3DSA:1.10.150.20 - - - 617 695 1.3E-8
Pfam PF01653 NAD-dependent DNA ligase adenylation domain IPR013839 NAD-dependent DNA ligase, adenylation 4 324 3.1E-127
FunFam G3DSA:2.40.50.140:FF:000012 DNA ligase - - 324 397 2.3E-34
Pfam PF03120 NAD-dependent DNA ligase OB-fold domain IPR004150 NAD-dependent DNA ligase, OB-fold 329 405 1.5E-34
SUPERFAMILY SSF52113 BRCT domain IPR036420 BRCT domain superfamily 705 779 6.54E-17
SMART SM00278 HhH1_4 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 531 550 140.0
Gene3D G3DSA:1.10.287.610 Helix hairpin bin - - 1 64 1.4E-27
Hamap MF_01588 DNA ligase [ligA]. IPR001679 NAD-dependent DNA ligase 2 778 51.916504
CDD cd00114 LIGANc IPR013839 NAD-dependent DNA ligase, adenylation 7 324 0.0
CDD cd17748 BRCT_DNA_ligase_like - - 707 777 1.45369E-23
FunFam G3DSA:1.10.287.610:FF:000002 DNA ligase - - 1 64 1.2E-28
FunFam G3DSA:1.10.150.20:FF:000006 DNA ligase - - 524 602 2.3E-23
FunFam G3DSA:1.10.150.20:FF:000007 DNA ligase - - 449 523 7.3E-29
SMART SM00278 HhH1_4 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 465 484 1.4
Gene3D G3DSA:3.30.470.30 DNA ligase/mRNA capping enzyme - - 65 322 8.6E-100
SMART SM00532 ligaN3 IPR013840 NAD-dependent DNA ligase, N-terminal 3 467 0.0
Gene3D G3DSA:1.10.150.20 - - - 524 605 4.6E-24
NCBIfam TIGR00575 JCVI: DNA ligase (NAD(+)) LigA IPR001679 NAD-dependent DNA ligase 11 609 0.0
Gene3D G3DSA:1.10.150.20 - - - 449 523 6.4E-28
Gene3D G3DSA:2.40.50.140 - IPR012340 Nucleic acid-binding, OB-fold 324 397 2.8E-32
PANTHER PTHR23389 CHROMOSOME TRANSMISSION FIDELITY FACTOR 18 - - 17 761 2.6E-49
SUPERFAMILY SSF50249 Nucleic acid-binding proteins IPR012340 Nucleic acid-binding, OB-fold 326 407 6.85E-28
Pfam PF00533 BRCA1 C Terminus (BRCT) domain IPR001357 BRCT domain 704 775 8.0E-10
SUPERFAMILY SSF56091 DNA ligase/mRNA capping enzyme, catalytic domain - - 3 323 5.4E-118
Coils Coil Coil - - 1 21 -
Pfam PF12826 Helix-hairpin-helix motif IPR041663 DisA/LigA, helix-hairpin-helix motif 625 679 8.9E-7
PIRSF PIRSF001604 LigA IPR001679 NAD-dependent DNA ligase 1 620 0.0
SMART SM00292 BRCT_7 IPR001357 BRCT domain 704 781 2.0E-8
PIRSF PIRSF001604 LigA IPR001679 NAD-dependent DNA ligase 611 783 5.3E-30
SUPERFAMILY SSF47781 RuvA domain 2-like IPR010994 RuvA domain 2-like 411 603 8.15E-54
Pfam PF12826 Helix-hairpin-helix motif IPR041663 DisA/LigA, helix-hairpin-helix motif 529 592 1.6E-19

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.