Pseudomonas stutzeri CCUG 29243, A458_11540 (ligA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006260 DNA replication
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF001604
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003911 DNA ligase (NAD+) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00532
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003677 DNA binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00278
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006281 DNA repair
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF001604
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Pathways

Database Xref Pathway Version Evidence PMID
KEGG psc03030 DNA replication 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG psc03430 Mismatch repair 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG psc03410 Base excision repair 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG psc03420 Nucleotide excision repair 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:2.40.50.140 - IPR012340 Nucleic acid-binding, OB-fold 327 400 2.3E-33
SUPERFAMILY SSF52113 BRCT domain IPR036420 BRCT domain superfamily 710 783 2.62E-16
Gene3D G3DSA:3.40.50.10190 BRCT domain IPR036420 BRCT domain superfamily 697 786 6.1E-24
FunFam G3DSA:3.30.470.30:FF:000001 DNA ligase - - 68 325 3.5E-107
PIRSF PIRSF001604 LigA IPR001679 NAD-dependent DNA ligase 617 788 8.8E-32
Gene3D G3DSA:1.10.150.20 - - - 527 607 1.7E-23
Hamap MF_01588 DNA ligase [ligA]. IPR001679 NAD-dependent DNA ligase 5 783 53.389015
SMART SM00278 HhH1_4 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 468 487 25.0
Gene3D G3DSA:6.20.10.30 - - - 401 451 1.9E-11
PIRSF PIRSF001604 LigA IPR001679 NAD-dependent DNA ligase 1 623 0.0
FunFam G3DSA:2.40.50.140:FF:000012 DNA ligase - - 327 400 6.7E-35
SUPERFAMILY SSF47781 RuvA domain 2-like IPR010994 RuvA domain 2-like 618 700 4.45E-13
SUPERFAMILY SSF56091 DNA ligase/mRNA capping enzyme, catalytic domain - - 5 326 1.66E-119
Gene3D G3DSA:1.10.287.610 Helix hairpin bin - - 2 68 3.5E-29
SUPERFAMILY SSF47781 RuvA domain 2-like IPR010994 RuvA domain 2-like 414 605 1.0E-51
Gene3D G3DSA:1.10.150.20 - - - 452 526 4.5E-26
Pfam PF00533 BRCA1 C Terminus (BRCT) domain IPR001357 BRCT domain 709 779 3.2E-9
SMART SM00292 BRCT_7 IPR001357 BRCT domain 709 786 1.5E-7
SMART SM00532 ligaN3 IPR013840 NAD-dependent DNA ligase, N-terminal 6 470 0.0
FunFam G3DSA:1.10.150.20:FF:000006 DNA ligase - - 528 605 1.5E-23
Gene3D G3DSA:3.30.470.30 DNA ligase/mRNA capping enzyme - - 69 325 5.8E-100
FunFam G3DSA:1.10.150.20:FF:000007 DNA ligase - - 452 527 2.8E-27
CDD cd00114 LIGANc IPR013839 NAD-dependent DNA ligase, adenylation 9 327 0.0
Pfam PF12826 Helix-hairpin-helix motif IPR041663 DisA/LigA, helix-hairpin-helix motif 627 683 1.0E-8
SUPERFAMILY SSF50249 Nucleic acid-binding proteins IPR012340 Nucleic acid-binding, OB-fold 328 410 2.23E-28
Pfam PF01653 NAD-dependent DNA ligase adenylation domain IPR013839 NAD-dependent DNA ligase, adenylation 7 328 6.2E-126
NCBIfam TIGR00575 JCVI: DNA ligase (NAD(+)) LigA IPR001679 NAD-dependent DNA ligase 14 610 0.0
Coils Coil Coil - - 659 679 -
Pfam PF03119 NAD-dependent DNA ligase C4 zinc finger domain IPR004149 Zinc-finger, NAD-dependent DNA ligase C4-type 417 456 1.5E-11
Pfam PF12826 Helix-hairpin-helix motif IPR041663 DisA/LigA, helix-hairpin-helix motif 532 595 3.3E-19
SMART SM00278 HhH1_4 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 534 553 190.0
Gene3D G3DSA:1.10.150.20 - - - 620 696 2.1E-11
FunFam G3DSA:1.10.287.610:FF:000002 DNA ligase - - 2 67 2.5E-29
SMART SM00278 HhH1_4 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 657 676 270.0
PANTHER PTHR23389 CHROMOSOME TRANSMISSION FIDELITY FACTOR 18 - - 16 767 8.7E-50
SMART SM00278 HhH1_4 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 502 521 710.0
CDD cd17748 BRCT_DNA_ligase_like - - 712 781 5.2377E-25
Pfam PF03120 NAD-dependent DNA ligase OB-fold domain IPR004150 NAD-dependent DNA ligase, OB-fold 332 408 2.8E-35

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.