Pseudomonas fluorescens SBW25, PFLU5416 (lipA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SFLDS00029
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF005963
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0051536 iron-sulfur cluster binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SFLDS00029
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016992 lipoate synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF005963
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009107 lipoate biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF005963
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Pathways

Database Xref Pathway Version Evidence PMID
KEGG (InterPro) 00785 Lipoic acid metabolism InterPro 5.8-49.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion 		0
UniPathway UPA00538 protein lipoylation via endogenous pathway InterPro 5.8-49.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion 		0

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF102114 Radical SAM enzymes - - 67 333 1.27E-68
Pfam PF04055 Radical SAM superfamily IPR007197 Radical SAM 108 267 2.6E-13
Gene3D G3DSA:3.20.20.70 Aldolase class I IPR013785 Aldolase-type TIM barrel 99 311 5.1E-21
SMART SM00729 MiaB IPR006638 Elp3/MiaA/NifB-like, radical SAM core domain 101 307 2.1E-15
NCBIfam TIGR00510 JCVI: lipoyl synthase IPR003698 Lipoyl synthase 50 331 1.2E-129
PIRSF PIRSF005963 Lipoyl_synth IPR003698 Lipoyl synthase 18 339 3.3E-130
SFLD SFLDS00029 Radical SAM IPR007197 Radical SAM 50 333 0.0
SFLD SFLDF00271 lipoyl synthase IPR003698 Lipoyl synthase 50 333 0.0
PANTHER PTHR10949 LIPOYL SYNTHASE IPR003698 Lipoyl synthase 51 332 7.5E-116
Hamap MF_00206 Lipoyl synthase [lipA]. IPR003698 Lipoyl synthase 53 340 152.667389
Pfam PF16881 N-terminal domain of lipoyl synthase of Radical_SAM family IPR031691 Lipoyl synthase, N-terminal 54 90 3.3E-7
CDD cd01335 Radical_SAM - - 108 283 1.6536E-5
FunFam G3DSA:3.20.20.70:FF:000023 Lipoyl synthase - - 98 309 1.0E-119

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.