Pseudomonas aeruginosa PAO1, PA4316 (sbcB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4316
Name
sbcB
Replicon chromosome
Genomic location 4844271 - 4845713 (- strand)
Transposon Mutants 9 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253006.1
GI 15599512
Affymetrix PA4316_sbcB_at
Entrez 881546
GenBank AAG07704.1
INSDC AAG07704.1
NCBI Locus Tag PA4316
protein_id(GenBank) gb|AAG07704.1|AE004848_3|gnl|PseudoCAP|PA4316
TIGR NTL03PA04317
UniParc UPI00000C5CB4
UniProtKB Acc Q9HW85
UniProtKB ID Q9HW85_PSEAE
UniRef100 UniRef100_Q9HW85
UniRef50 UniRef50_Q9HW85
UniRef90 UniRef90_Q9HW85

Product

Feature Type CDS
Coding Frame 1
Product Name
exodeoxyribonuclease I
Product Name Confidence: Class 2
Synonyms DNA deoxyribophosphodiesterase
exonuclease I, dRpase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -9.87
Kyte-Doolittle Hydrophobicity Value -0.520
Molecular Weight (kDa) 55.4
Isoelectric Point (pI) 5.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 114 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003914 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4316
Search term: sbcB

Human Homologs

References

Determination of the nucleotide sequence for the exonuclease I structural gene (sbcB) of Escherichia coli K12.
Phillips GJ, Kushner SR
J Biol Chem 1987 Jan 5;262(1):455-9
PubMed ID: 3539937
DNA deoxyribophosphodiesterase of Escherichia coli is associated with exonuclease I.
Sandigursky M, Franklin WA
Nucleic Acids Res 1992 Sep 25;20(18):4699-703
PubMed ID: 1329027