Pseudomonas aeruginosa PAO1, PA2252

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2252
Name
Replicon chromosome
Genomic location 2479299 - 2480744 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250942.1
GI 15597448
Affymetrix PA2252_at
Entrez 878283
GenBank AAG05640.1
INSDC AAG05640.1
NCBI Locus Tag PA2252
protein_id(GenBank) gb|AAG05640.1|AE004651_2|gnl|PseudoCAP|PA2252
TIGR NTL03PA02252
UniParc UPI00000C562F
UniProtKB Acc Q9I1L7
UniProtKB ID Q9I1L7_PSEAE
UniRef100 UniRef100_S0I4P9
UniRef50 UniRef50_Q4K3I6
UniRef90 UniRef90_A0A024HII3

Product

Feature Type CDS
Coding Frame 1
Product Name
probable AGCS sodium/alanine/glycine symporter
Product Name Confidence: Class 3
Synonyms probable amino acid transporter
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected using LC-MS/MS (51.52 kDa, PMID:21751344)
Charge (pH 7) 5.52
Kyte-Doolittle Hydrophobicity Value 0.675
Molecular Weight (kDa) 51.5
Isoelectric Point (pI) 8.66

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Outer Membrane Vesicle Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 315 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003237 (513 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2252

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344