Pseudomonas aeruginosa PAO1, PA1798 (parS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1798
Name
parS
Replicon chromosome
Genomic location 1950439 - 1951725 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250489.1
GI 15596995
Affymetrix PA1798_at
Entrez 878335
GenBank AAG05187.1
INSDC AAG05187.1
NCBI Locus Tag PA1798
protein_id(GenBank) gb|AAG05187.1|AE004606_1|gnl|PseudoCAP|PA1798
TIGR NTL03PA01799
UniParc UPI00000C54A2
UniProtKB Acc Q9I2U4
UniProtKB ID Q9I2U4_PSEAE
UniRef100 UniRef100_Q9I2U4
UniRef50 UniRef50_Q9I2U4
UniRef90 UniRef90_Q9I2U4

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component sensor, ParS
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -12.93
Kyte-Doolittle Hydrophobicity Value -0.159
Molecular Weight (kDa) 48.4
Isoelectric Point (pI) 5.23

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
ParS ParS is the sensor component of the two-component ParRS system. Alongside its counterpart ParR, it confers resistance to polycationic antibiotics though regulation of efflux pumps and porins. [PMID:18978025, PMID:21149619, PMID:10984043, PMID:15608211] ARO:3005067 protein homolog model Perfect 829.3 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 621 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003599 (458 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1798
Search term: parS

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
In vivo characterization of tus gene expression in Escherichia coli.
Roecklein BA, Kuempel PL
Mol Microbiol 1992 Jun;6(12):1655-61
PubMed ID: 1495392