Pseudomonas aeruginosa PAO1, PA1120 (tpbB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0052621 diguanylate cyclase activity
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA14_49890
 ECO:0000250
sequence similarity evidence used in manual assertion		 19543378 Reviewed by curator
Molecular Function GO:0052621 diguanylate cyclase activity
IDA
Inferred from Direct Assay 		ECO:0000005
enzyme assay evidence		 16477007 Reviewed by curator
Molecular Function GO:0052621 diguanylate cyclase activity
IMP
Inferred from Mutant Phenotype 		ECO:0000015
mutant phenotype evidence		 19543378 Reviewed by curator
Biological Process GO:0007165 signal transduction
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00304
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0016020 membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00304
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PAO1 genes in this class
Membrane proteins Other PAO1 genes in this class
Motility & Attachment Other PAO1 genes in this class
Cell wall / LPS / capsule Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae02025 Biofilm formation - Pseudomonas aeruginosa 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
CDD cd01949 GGDEF IPR000160 GGDEF domain 250 406 5.70956E-60
NCBIfam TIGR00254 JCVI: diguanylate cyclase (GGDEF) domain IPR000160 GGDEF domain 245 408 3.7E-44
MobiDBLite mobidb-lite consensus disorder prediction - - 413 429 -
SUPERFAMILY SSF55073 Nucleotide cyclase IPR029787 Nucleotide cyclase 254 408 1.02E-44
Gene3D G3DSA:3.30.70.270 - IPR043128 Reverse transcriptase/Diguanylate cyclase domain 254 413 4.6E-55
FunFam G3DSA:3.30.70.270:FF:000090 Diguanylate cyclase TpbB - - 254 413 2.5E-106
MobiDBLite mobidb-lite consensus disorder prediction - - 413 435 -
CDD cd06225 HAMP - - 186 231 4.22773E-5
SMART SM00304 HAMP_11 IPR003660 HAMP domain 183 236 9.6E-8
Pfam PF00672 HAMP domain IPR003660 HAMP domain 181 232 5.5E-9
SMART SM00267 duf1_3 IPR000160 GGDEF domain 238 411 2.0E-56
Gene3D G3DSA:6.10.340.10 - - - 145 241 8.7E-8
Coils Coil Coil - - 217 244 -
Pfam PF00990 Diguanylate cyclase, GGDEF domain IPR000160 GGDEF domain 249 405 1.4E-46
Pfam PF17152 Periplasmic sensor domain IPR033417 Periplasmic sensor domain CHASE8 45 145 7.4E-33
PANTHER PTHR46663 DIGUANYLATE CYCLASE DGCT-RELATED - - 117 427 1.1E-74

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.