Pseudomonas protegens CHA0, PFLCHA0_c06640 (cobG)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas protegens CHA0 - Assembly GCF_000397205.1
GCF_000397205.1|latest |
| Locus Tag |
PFLCHA0_c06640
|
| Name |
cobG
|
| Replicon | chromosome |
| Genomic location | 766715 - 768028 (+ strand) |
| Comment | Incorrectly identified previously as NirA due to containing Nitrite/Sulphite reductase ferredoxin-like half domains which are domains also found in CobG. |
| Comment | Monooxygenase which converts Precorrin-3A to Precorrin-3b as part of vitamin B12 biosynthesis pathway [PMID:19068481] |
Cross-References
| RefSeq | YP_007997967.1 |
| GI | 501678141 |
| Entrez | 15558580 |
| NCBI Locus Tag | PFLCHA0_c06640 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
CobG
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -3.93 |
| Kyte-Doolittle Hydrophobicity Value | 0.133 |
| Molecular Weight (kDa) | 45722.9 |
| Isoelectric Point (pI) | 6.50 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 310 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG002668 (498 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PFLCHA0_c06640
Search term: cobG
Search term: CobG
|
Human Homologs
References
|
Demonstration that CobG, the monooxygenase associated with the ring contraction process of the aerobic cobalamin (vitamin B12) biosynthetic pathway, contains an Fe-S center and a mononuclear non-heme iron center.
Schroeder S, Lawrence AD, Biedendieck R, Rose RS, Deery E, Graham RM, McLean KJ, Munro AW, Rigby SE, Warren MJ
J Biol Chem 2009 Feb 20;284(8):4796-805
PubMed ID: 19068481
|