Pseudomonas aeruginosa UCBPP-PA14, PA14_40290 (lasA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_40290
Name
lasA
Replicon chromosome
Genomic location 3599215 - 3600471 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_791368.1
GI 116049825
Entrez 4382361
INSDC ABJ11061.1
NCBI Locus Tag PA14_40290
UniParc UPI00003968B7
UniProtKB Acc Q02L18
UniProtKB ID LASA_PSEAB
UniRef100 UniRef100_Q02L18
UniRef50 UniRef50_P14789
UniRef90 UniRef90_P14789

Product

Feature Type CDS
Coding Frame 1
Product Name
LasA protease
Synonyms
Evidence for Translation
Charge (pH 7) 9.26
Kyte-Doolittle Hydrophobicity Value -0.271
Molecular Weight (kDa) 45.6
Isoelectric Point (pI) 9.18

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3IT5 HYDROLASE 08/27/09 Crystal Structure of the LasA Virulence Factor from Pseudomonas aeruginosa Pseudomonas aeruginosa 2 X-RAY DIFFRACTION 99.5
3IT7 HYDROLASE 08/27/09 Crystal Structure of the LasA virulence factor from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.14 X-RAY DIFFRACTION 99.5

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 55 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003532 (299 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_40290
Search term: lasA
Search term: LasA protease

Human Homologs

References

No references are associated with this feature.