Pseudomonas fluorescens SBW25, PFLU0953 (lpxC)

Gene Feature Overview

Strain	Pseudomonas fluorescens SBW25 GCF_000009225.2|latest
Locus Tag	PFLU0953
Name	lpxC
Replicon	chromosome
Genomic location	1058454 - 1059365 (+ strand)

Cross-References

RefSeq	YP_002870615.1
GI	229588496
Entrez	7817357
INSDC	CAY47219.1
UniParc	UPI00019D9E74
UniProtKB Acc	C3KDE0
UniProtKB ID	LPXC_PSEFS
UniRef100	UniRef100_C3KDE0
UniRef50	UniRef50_Q6D0I9
UniRef90	UniRef90_Q87WZ1

Product

Feature Type	CDS
Coding Frame	1
Product Name	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
Synonyms
Evidence for Translation
Charge (pH 7)	-12.54
Kyte-Doolittle Hydrophobicity Value	-0.004
Molecular Weight (kDa)	33.2
Isoelectric Point (pI)	4.67

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
5DRQ	hydrolase/hydrolase inhibitor	09/16/15	Crystal structure of the Pseudomonas aeruginosa LpxC/LPC-040 complex	Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)	1.63	X-RAY DIFFRACTION	91.6
5U3B	HYDROLASE	12/01/16	Pseudomonas aeruginosa LpxC in complex with NVS-LPXC-01	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	2	X-RAY DIFFRACTION	91.6
5N8C	HYDROLASE	02/23/17	Crystal structure of Pseudomonas aeruginosa LpxC complexed with inhibitor	Pseudomonas aeruginosa	1.9	X-RAY DIFFRACTION	91.4
3P3E	HYDROLASE	10/04/10	Crystal Structure of the PSEUDOMONAS AERUGINOSA LpxC/LPC-009 complex	Pseudomonas aeruginosa	1.28	X-RAY DIFFRACTION	91.6
7K99	HYDROLASE	09/28/20	Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor 19	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	1.9	X-RAY DIFFRACTION	91.4
6DUI	hydrolase/hydrolase inhibitor	06/20/18	Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PT801	Pseudomonas aeruginosa (strain LESB58)	1.55	X-RAY DIFFRACTION	91.4
5VWM	Hydrolase/Hydrolase Inhibitor	05/22/17	Crystal structure of UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) from Pseudomonas aeruginosa in complex with CHIR-090 inhibitor	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	1.8	X-RAY DIFFRACTION	91.4
8E4A	BIOSYNTHETIC PROTEIN	08/17/22	Pseudomonas LpxC in complex with LPC-233	Pseudomonas aeruginosa	2.034	X-RAY DIFFRACTION	91.6
7CIC	HYDROLASE	07/07/20	Crystal structure of P.aeruginosa LpxC in complex with inhibitor	Pseudomonas aeruginosa PAO1	1.78	X-RAY DIFFRACTION	91.6
6MAE	HYDROLASE	08/27/18	CHAIN A. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase PA-LPXC Complexed with (R)-3-((S)-3-(4-(cyclopropylethynyl)phenyl)-2-oxooxazolidin-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)propenamide	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	1.8	X-RAY DIFFRACTION	91.6
4LCG	HYDROLASE/ANTIBIOTIC	06/21/13	Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-050 complex	Pseudomonas aeruginosa	1.568	X-RAY DIFFRACTION	91.6
7K9A	HYDROLASE	09/29/20	Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	2	X-RAY DIFFRACTION	91.4
5UPG	HYDROLASE	02/02/17	Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PF-5081090	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	1.7	X-RAY DIFFRACTION	91.4
4LCF	HYDROLASE/ANTIBIOTIC	06/21/13	Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-014 complex	Pseudomonas aeruginosa	1.599	X-RAY DIFFRACTION	91.6
6CAX	hydrolase/hydrolase inhibitor	02/01/18	Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PT805	Pseudomonas aeruginosa	1.25	X-RAY DIFFRACTION	91.4
4OKG	HYDROLASE/HYDROLASE INHIBITOR	01/22/14	LpxC from P.aeruginosa with the inhibitor 6-(benzimidazol-1-yl)-5-[4-[2-[6-[(4-methylpiperazin-1-yl)methyl]-3-pyridyl]ethynyl]phenyl]pyridine-3-carbohydroxamic acid	Pseudomonas aeruginosa	2.06	X-RAY DIFFRACTION	91.6
4FW7	HYDROLASE/HYDROLASE INHIBITOR	06/30/12	Crystal Structure of the LpxC in complex with N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBUTAN-2-YL]BIPHENYL-4-CARBOXAMIDE inhibitor	Pseudomonas aeruginosa	1.7	X-RAY DIFFRACTION	91.6
6C9C	hydrolase/hydrolase inhibitor	01/26/18	Crystal structure of LpxC from Pseudomonas aeruginosa in complex with racemic ligand PT803	Pseudomonas aeruginosa (strain UCBPP-PA14)	2	X-RAY DIFFRACTION	91.4
6E54	hydrolase/hydrolase inhibitor	07/19/18	Crystal structure of LpxC from Pseudomonas aeruginosa in complex with ligand PT802	Pseudomonas aeruginosa	1.65	X-RAY DIFFRACTION	91.4

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 387 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG003996 (535 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PFLU0953 Search term: lpxC Search term: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Human Homologs

References