Pseudomonas sp. HPB0071, HMPREF1487_05370

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas sp. HPB0071
GCF_000478505.2|latest
Locus Tag
HMPREF1487_05370
NCBI Locus TagHMPREF1487_RS05330
Name
Replicon scaffold_1
Genomic location 1066417 - 1069554 (- strand)

Cross-References

RefSeq WP_010795578.1
GI 498494843
INSDC ENA36007.1
NCBI Locus Tag HMPREF1487_RS05330
NCBI Old Locus Tag HMPREF1487_05370
UniParc UPI0002CBF0C1
UniProtKB Acc N2J8W5
UniProtKB ID N2J8W5_9PSED
UniRef100 UniRef100_N2J8W5
UniRef50 UniRef50_P24177
UniRef90 UniRef90_N2J8W5

Product

Feature Type CDS
Coding Frame 1
Product Name
multidrug resistance protein MexB
Synonyms
Evidence for Translation
Charge (pH 7) -7.86
Kyte-Doolittle Hydrophobicity Value 0.219
Molecular Weight (kDa) 113.4
Isoelectric Point (pI) 5.65

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Dequalinium DB04209 DrugBank 5.1.4 P31224 Multidrug efflux pump subunit AcrB 66.6 1049 0.0e+00
Rhodamine 6G DB03825 DrugBank 5.1.4 P31224 Multidrug efflux pump subunit AcrB 66.6 1049 0.0e+00
Deoxycholic Acid DB03619 DrugBank 5.1.4 P31224 Multidrug efflux pump subunit AcrB 66.6 1049 0.0e+00

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000417 (2093 members)
Putative Inparalogs 1 predicted inparalogs
hydrophobe/amphiphile efflux-1 (HAE1) family RND transporter (HMPREF1487_08517) 53.9% identity

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: HMPREF1487_05370

Human Homologs

References

No references are associated with this feature.