Pseudomonas sp. VLB120, PVLB_10020

Gene Feature Overview

Strain	Pseudomonas sp. VLB120 GCF_000494915.1|latest
Locus Tag	PVLB_10020
Name
Replicon	chromosome
Genomic location	2205647 - 2207086 (- strand)

Cross-References

RefSeq	YP_008762927.1
GI	557222712
EC Number	3.5.2.-
Entrez	17496616
INSDC	AGZ34800.1
NCBI Locus Tag	PVLB_10020
UniParc	UPI0003C09E67
UniProtKB Acc	U5VGG0
UniProtKB ID	U5VGG0_9PSED
UniRef100	UniRef100_U5VGG0
UniRef50	UniRef50_Q59699
UniRef90	UniRef90_Q9I676

Product

Feature Type	CDS
Coding Frame	1
Product Name	phenylhydantoinase
Synonyms
Evidence for Translation
Charge (pH 7)	-10.15
Kyte-Doolittle Hydrophobicity Value	-0.229
Molecular Weight (kDa)	52.5
Isoelectric Point (pI)	6.14

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
7E3U	HYDROLASE	02/09/21	Crystal structure of the Pseudomonas aeruginosa dihydropyrimidinase complexed with 5-AU	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	2.159	X-RAY DIFFRACTION	90.4
6AJD	HYDROLASE	08/27/18	Crystal structure of a monometallic dihydropyrimidinase from Pseudomonas aeruginosa PAO1 reveals no lysine carbamylation within the active site	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	2.223	X-RAY DIFFRACTION	90.6
6KLK	HYDROLASE	07/30/19	Crystal structure of the Pseudomonas aeruginosa dihydropyrimidinase complexed with 5-FU	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	1.759	X-RAY DIFFRACTION	90.4
5E5C	HYDROLASE	10/08/15	Crystal structure of dihydropyrimidinase from Pseudomonas aeruginosa PAO1	Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)	2.1	X-RAY DIFFRACTION	90.6
5YKD	HYDROLASE	10/14/17	Crystal structure of dihydropyrimidinase from Pseudomonas aeruginosa PAO1 at 2.17 angstrom resolution	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	2.17	X-RAY DIFFRACTION	90.4

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 560 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000432 (819 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PVLB_10020 Search term: phenylhydantoinase

Human Homologs

Ensembl 110, assembly GRCh38.p14

ENSP00000276651 dihydropyrimidinase [Source:HGNC Symbol;Acc:HGNC:3013] E-value: 3.4e-138 Percent Identity: 51.0

References