Pseudomonas aeruginosa BWHPSA008, Q021_04730
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa BWHPSA008
GCF_000481545.1|latest |
| Locus Tag |
Q021_04730
|
| Name |
|
| Replicon | scaffold_2 |
| Genomic location | 1556792 - 1558102 (- strand) |
Cross-References
| RefSeq | WP_003110461.1 |
| GI | 489201271 |
| NCBI Locus Tag | Q021_04730 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
GDP-mannose 6-dehydrogenase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -9.09 |
| Kyte-Doolittle Hydrophobicity Value | -0.051 |
| Molecular Weight (kDa) | 47.6 |
| Isoelectric Point (pI) | 5.35 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 1MV8 | OXIDOREDUCTASE | 09/24/02 | 1.55 A crystal structure of a ternary complex of GDP-mannose dehydrogenase from Psuedomonas aeruginosa | Pseudomonas aeruginosa | 1.55 | X-RAY DIFFRACTION | 100.0 |
| 1MUU | OXIDOREDUCTASE | 09/24/02 | 2.0 A crystal structure of GDP-mannose dehydrogenase | Pseudomonas aeruginosa | 2.02 | X-RAY DIFFRACTION | 100.0 |
| 1MFZ | OXIDOREDUCTASE | 08/14/02 | Partially refined 2.8 A Crystal structure of GDP-mannose dehydrogenase from P. aeruginosa | Pseudomonas aeruginosa | 2.8 | X-RAY DIFFRACTION | 100.0 |
Drugs Targeting this Protein
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
| Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
| Sucrose | DB02772 | DrugBank | 5.1.4 | P11759 | GDP-mannose 6-dehydrogenase | 100.0 | 436 | 7.2e-252 |
| Guanosine 5'-(Trihydrogen Diphosphate), P'-D-Mannopyranosyl Ester | DB04023 | DrugBank | 5.1.4 | P11759 | GDP-mannose 6-dehydrogenase | 100.0 | 436 | 7.2e-252 |
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG002126 (490 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: Q021_04730
Search term: GDP-mannose 6-dehydrogenase
|
Human Homologs
References
No references are associated with this feature.