Pseudomonas aeruginosa BWHPSA015, Q028_02323

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa BWHPSA015
GCF_000481405.1|latest
Locus Tag
Q028_02323
Name
Replicon scaffold_1
Genomic location 2572998 - 2574191 (+ strand)

Cross-References

RefSeq WP_003121934.1
GI 489213196
NCBI Locus Tag Q028_02323

Product

Feature Type CDS
Coding Frame 1
Product Name
beta-lactamase
Synonyms
Evidence for Translation
Charge (pH 7) 4.38
Kyte-Doolittle Hydrophobicity Value -0.284
Molecular Weight (kDa) 43.4
Isoelectric Point (pI) 8.82

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
PDC-3 PDC-3 is a extended-spectrum beta-lactamase found in Pseudomonas aeruginosa. [PMID:19258272, PMID:33416461] ARO:3002500 protein homolog model Perfect 807.0 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4GZB HYDROLASE 09/06/12 Crystal structure of native AmpC beta-lactamase from Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa 1.79 X-RAY DIFFRACTION 99.7
6UQT ANTIBIOTIC 10/21/19 Serendipitous Discovery of Aryl Boronic Acids as beta-Lactamase Inhibitors Pseudomonas aeruginosa 1.25 X-RAY DIFFRACTION 99.7
8SDR HYDROLASE/HYDROLASE INHIBITOR 04/07/23 Crystal structure of PDC-3 beta-lactamase in complex with the boronic acid inhibitor LP-06 Pseudomonas aeruginosa 1.35 X-RAY DIFFRACTION 100.0
4OOY hydrolase/hydrolase inhibitor 02/04/14 Avibactam and class C beta-lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance Pseudomonas aeruginosa 1.1 X-RAY DIFFRACTION 99.7
4NK3 HYDROLASE/HYDROLASE INHIBITOR 11/12/13 Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655 Pseudomonas aeruginosa 1.9 X-RAY DIFFRACTION 99.7
6I30 HYDROLASE 11/02/18 Crystal structure of the AmpC from Pseudomonas aeruginosa with 1C Pseudomonas aeruginosa 2.21 X-RAY DIFFRACTION 99.7
8SDT HYDROLASE 04/07/23 Crystal structure of PDC-3 beta-lactamase in complex with the boronic acid inhibitor S02030 Pseudomonas aeruginosa 1.38 X-RAY DIFFRACTION 100.0
4WZ4 hydrolase/hydrolase inhibitor 11/18/14 Crystal structure of P. aeruginosa AmpC Pseudomonas aeruginosa PAO1 1.05 X-RAY DIFFRACTION 99.7
4HEF HYDROLASE/HYDROLASE INHIBITOR 10/03/12 Structure of avibactam bound to Pseudomonas aeruginosa AmpC Pseudomonas aeruginosa 1.86 X-RAY DIFFRACTION 99.4
3S22 Hydrolase/Hydrolase Inhibitor 05/16/11 AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA) in complex with an inhibitor Pseudomonas aeruginosa 1.65 X-RAY DIFFRACTION 99.7
8SDS HYDROLASE 04/07/23 Crystal structure of PDC-3 Y221H beta-lactamase in complex with the boronic acid inhibitor LP-06 Pseudomonas aeruginosa 1.63 X-RAY DIFFRACTION 99.7
2WZX HYDROLASE 12/03/09 AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA)IN COMPLEX WITH compound M-02 PSEUDOMONAS AERUGINOSA 1.4 X-RAY DIFFRACTION 99.7
6S1S HYDROLASE 06/19/19 Crystal structure of AmpC from Pseudomonas aeruginosa in complex with [3-(2-carboxyvinyl)phenyl]boronic acid] inhibitor Pseudomonas aeruginosa 1.78 X-RAY DIFFRACTION 99.7
8SDN HYDROLASE 04/07/23 Crystal structure of PDC-3 Y221H beta-lactamase Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 99.7
8SDL HYDROLASE 04/07/23 Crystal structure of PDC-3 beta-lactamase Pseudomonas aeruginosa 1.75 X-RAY DIFFRACTION 100.0
6UR3 ANTIBIOTIC 10/22/19 Serendipitous Discovery of Aryl Boronic Acids as beta-Lactamase Inhibitors Pseudomonas aeruginosa 1.423 X-RAY DIFFRACTION 99.7
8SDV HYDROLASE 04/07/23 Crystal structure of PDC-3 Y221H beta-lactamase in complex with the boronic acid inhibitor S02030 Pseudomonas aeruginosa 1.42 X-RAY DIFFRACTION 99.7
3S1Y Hydrolase/Hydrolase Inhibitor 05/16/11 AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA) in complex with a beta-lactamase inhibitor Pseudomonas aeruginosa 1.4 X-RAY DIFFRACTION 99.7
4X68 HYDROLASE/HYDROLASE INHIBITOR 12/07/14 Crystal Structure of OP0595 complexed with AmpC Pseudomonas aeruginosa 1.68 X-RAY DIFFRACTION 99.7
6UQS ANTIBIOTIC 10/21/19 Serendipitous Discovery of Aryl Boronic Acids as beta-Lactamase Inhibitors Pseudomonas aeruginosa 1.37 X-RAY DIFFRACTION 99.7
2WZZ HYDROLASE 12/03/09 AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA)IN COMPLEX WITH compound M-03 PSEUDOMONAS AERUGINOSA 1.57 X-RAY DIFFRACTION 99.7
6UQU ANTIBIOTIC 10/21/19 Serendipitous Discovery of Aryl Boronic Acids as beta-Lactamase Inhibitors Pseudomonas aeruginosa 1.0902 X-RAY DIFFRACTION 99.7
4WYY hydrolase/hydrolase inhibitor 11/18/14 Crystal Structure of P. aeruginosa AmpC Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) 1.28 X-RAY DIFFRACTION 99.7

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001588 (493 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Q028_02323
Search term: beta-lactamase

Human Homologs

References

No references are associated with this feature.