Pseudomonas aeruginosa NCGM2.S1, NCGM2_RS28605

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006935 chemotaxis
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00260
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0000155 phosphorelay sensor kinase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM01231
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0005737 cytoplasm
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM01231
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016772 transferase activity, transferring phosphorus-containing groups
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00344
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004673 protein histidine kinase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM01231
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0016310 phosphorylation
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00344
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0000160 phosphorelay signal transduction system
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd00088
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0007165 signal transduction
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00260
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pnc02025 Biofilm formation - Pseudomonas aeruginosa 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pnc02020 Two-component system 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
CDD cd00088 HPT IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 1360 1458 4.01183E-15
SMART SM00073 hpt_2 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 1526 1623 0.011
CDD cd00088 HPT IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 1674 1778 6.05116E-13
FunFam G3DSA:3.30.565.10:FF:000016 Chemotaxis protein CheA, putative - - 1995 2179 1.7E-60
Pfam PF01627 Hpt domain IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 1362 1455 5.0E-14
Coils Coil Coil - - 1893 1913 -
Coils Coil Coil - - 1756 1783 -
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 2164 2177 1.5E-10
Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IPR003594 Histidine kinase/HSP90-like ATPase 2043 2179 1.8E-16
Gene3D G3DSA:1.20.120.160 HPT domain IPR036641 HPT domain superfamily 1360 1490 2.0E-29
SUPERFAMILY SSF47226 Histidine-containing phosphotransfer domain, HPT domain IPR036641 HPT domain superfamily 1526 1648 1.28E-26
Coils Coil Coil - - 1368 1388 -
SMART SM00260 chew_2 IPR002545 CheW-like domain 2172 2322 2.0E-34
Gene3D G3DSA:2.30.30.40 SH3 Domains - - 2260 2320 2.9E-19
CDD cd00088 HPT IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 1526 1624 4.59779E-15
Pfam PF01627 Hpt domain IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 1675 1769 6.7E-15
SUPERFAMILY SSF47226 Histidine-containing phosphotransfer domain, HPT domain IPR036641 HPT domain superfamily 862 987 7.33E-27
Pfam PF01627 Hpt domain IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 864 954 8.4E-14
Pfam PF01584 CheW-like domain IPR002545 CheW-like domain 2185 2324 1.2E-22
SMART SM00073 hpt_2 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 1673 1770 6.4E-4
Pfam PF01627 Hpt domain IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 1528 1627 3.8E-14
CDD cd17546 REC_hyHK_CKI1_RcsC-like - - 2357 2468 3.63361E-30
SMART SM00448 REC_2 IPR001789 Signal transduction response regulator, receiver domain 2355 2468 2.9E-37
Gene3D G3DSA:1.20.120.160 HPT domain IPR036641 HPT domain superfamily 1033 1168 5.3E-18
SMART SM00073 hpt_2 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 1360 1457 6.6E-7
MobiDBLite mobidb-lite consensus disorder prediction - - 984 1033 -
PANTHER PTHR43395 SENSOR HISTIDINE KINASE CHEA - - 1399 1669 0.0
Pfam PF00072 Response regulator receiver domain IPR001789 Signal transduction response regulator, receiver domain 2357 2469 1.6E-27
MobiDBLite mobidb-lite consensus disorder prediction - - 564 610 -
Gene3D G3DSA:1.20.120.160 HPT domain IPR036641 HPT domain superfamily 14 137 1.3E-11
SUPERFAMILY SSF47226 Histidine-containing phosphotransfer domain, HPT domain IPR036641 HPT domain superfamily 433 556 1.94E-14
CDD cd16916 HATPase_CheA-like - - 2002 2177 1.11228E-83
Gene3D G3DSA:3.30.565.10 - IPR036890 Histidine kinase/HSP90-like ATPase superfamily 1993 2179 1.0E-52
SMART SM01231 H_kinase_dim_2 IPR004105 Histidine kinase CheA-like, homodimeric domain 1855 1994 1.3E-11
SUPERFAMILY SSF50341 CheW-like IPR036061 CheW-like domain superfamily 2179 2318 1.7E-21
CDD cd00088 HPT IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 862 958 3.5129E-10
SMART SM00387 HKATPase_4 IPR003594 Histidine kinase/HSP90-like ATPase 2039 2180 1.3E-22
SUPERFAMILY SSF47226 Histidine-containing phosphotransfer domain, HPT domain IPR036641 HPT domain superfamily 1039 1162 2.88E-19
Pfam PF01627 Hpt domain IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 10 98 3.0E-8
Pfam PF01627 Hpt domain IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 1041 1127 3.8E-11
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 2084 2098 1.5E-10
Gene3D G3DSA:1.20.120.160 HPT domain IPR036641 HPT domain superfamily 1183 1310 1.4E-12
SUPERFAMILY SSF47226 Histidine-containing phosphotransfer domain, HPT domain IPR036641 HPT domain superfamily 1182 1302 1.53E-13
SUPERFAMILY SSF47226 Histidine-containing phosphotransfer domain, HPT domain IPR036641 HPT domain superfamily 1674 1782 3.79E-20
Gene3D G3DSA:3.40.50.2300 - - - 2357 2476 5.3E-40
Coils Coil Coil - - 232 252 -
Gene3D G3DSA:1.20.120.160 HPT domain IPR036641 HPT domain superfamily 1667 1800 2.2E-23
SMART SM00073 hpt_2 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 1039 1134 0.51
SUPERFAMILY SSF47226 Histidine-containing phosphotransfer domain, HPT domain IPR036641 HPT domain superfamily 7 130 1.96E-23
SUPERFAMILY SSF52172 CheY-like IPR011006 CheY-like superfamily 2354 2473 3.98E-36
CDD cd00088 HPT IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 1039 1130 2.28052E-5
Gene3D G3DSA:1.20.120.160 HPT domain IPR036641 HPT domain superfamily 1526 1655 7.3E-27
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 2140 2158 1.5E-10
MobiDBLite mobidb-lite consensus disorder prediction - - 620 639 -
SUPERFAMILY SSF55874 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase IPR036890 Histidine kinase/HSP90-like ATPase superfamily 1996 2177 7.99E-36
Gene3D G3DSA:1.20.120.160 HPT domain IPR036641 HPT domain superfamily 862 991 1.8E-27
SMART SM00073 hpt_2 IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain 862 959 1.6E-6
SUPERFAMILY SSF47226 Histidine-containing phosphotransfer domain, HPT domain IPR036641 HPT domain superfamily 1360 1482 7.07E-28

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.