Pseudomonas aeruginosa LESB58, PALES_40681 (qslA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa LESB58
GCF_000026645.1|latest |
| Locus Tag |
PALES_40681
|
| Name |
qslA
|
| Replicon | chromosome |
| Genomic location | 4492600 - 4492941 (+ strand) |
Cross-References
| RefSeq | YP_002441651 |
| GI | 218892782 |
| Entrez | 7178193 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
QslA
|
| Synonyms |
LasR-specific antiactivator QslA |
| Evidence for Translation | |
| Charge (pH 7) | 0.23 |
| Kyte-Doolittle Hydrophobicity Value | -0.453 |
| Molecular Weight (kDa) | 12.8 |
| Isoelectric Point (pI) | 7.54 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 4NG2 | Transcription Regulator | 11/01/13 | Crystal structure of LasR LBD-QslA complex from Pseudomonas aeruginosa | Pseudomonas aeruginosa | 2.413 | X-RAY DIFFRACTION | 99.1 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in one genus
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG001196 (298 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PALES_40681
Search term: qslA
Search term: QslA
|
Human Homologs
References
|
Differential Modulation of Quorum Sensing Signaling through QslA in Pseudomonas aeruginosa Strains PAO1 and PA14.
Sana TG, Lomas R, Gimenez MR, Laubier A, Soscia C, Chauvet C, Conesa A, Voulhoux R, Ize B, Bleves S
J Bacteriol 2019 Nov 1;201(21)
PubMed ID: 31405911
|
|
QsIA disrupts LasR dimerization in antiactivation of bacterial quorum sensing.
Fan H, Dong Y, Wu D, Bowler MW, Zhang L, Song H
Proc Natl Acad Sci U S A 2013 Dec 17;110(51):20765-70
PubMed ID: 24319092
|