Pseudomonas aeruginosa LESB58, PALES_10931 (tpbA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa LESB58
GCF_000026645.1|latest
Locus Tag
PALES_10931
Name
tpbA
Replicon chromosome
Genomic location 1184808 - 1185464 (- strand)

Cross-References

RefSeq
GI 218889835

Product

Feature Type CDS
Coding Frame 1
Product Name
protein tyrosine phosphatase TpbA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 0.59
Kyte-Doolittle Hydrophobicity Value -0.123
Molecular Weight (kDa) 24004.3
Isoelectric Point (pI) 7.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Periplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4R0S HYDROLASE 08/01/14 Crystal structure of P. aeruginosa TpbA Pseudomonas aeruginosa PAO1 2.03 X-RAY DIFFRACTION 99.5
4R0T HYDROLASE 08/01/14 Crystal structure of P. aeruginosa TpbA (C132S) in complex with pTyr Pseudomonas aeruginosa PAO1 2.603 X-RAY DIFFRACTION 99.1
2M3V HYDROLASE 01/26/13 Solution structure of tyrosine phosphatase related to biofilm formation A (TpbA) from Pseudomonas aeruginosa Pseudomonas aeruginosa NOT SOLUTION NMR 96.9

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 32 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001786 (406 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PALES_10931
Search term: tpbA

Human Homologs

References

Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885).
Ueda A, Wood TK
PLoS Pathog 2009 Jun;5(6):e1000483
PubMed ID: 19543378