Pseudomonas aeruginosa NCGM1900, NCGM1900_RS22915
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Molecular Function | GO:0008270 | zinc ion binding |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000381
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0042558 | pteridine-containing compound metabolic process |
Inferred from Sequence Model
Term mapped from: InterPro:PF00809
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0009086 | methionine biosynthetic process |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000381
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0008705 | methionine synthase activity |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000381
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0046872 | metal ion binding |
Inferred from Sequence Model
Term mapped from: InterPro:SSF52242
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0044237 | cellular metabolic process |
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.20.20.20
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0031419 | cobalamin binding |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000381
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Functional Classifications Manually Assigned by PseudoCAP
|
|
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| KEGG | paeb01100 | Metabolic pathways | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | paeb00670 | One carbon pool by folate | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | paeb01110 | Biosynthesis of secondary metabolites | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | paeb00270 | Cysteine and methionine metabolism | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | paeb00450 | Selenocompound metabolism | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | paeb01230 | Biosynthesis of amino acids | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| PANTHER | PTHR45833 | METHIONINE SYNTHASE | - | - | 13 | 1232 | 0.0 |
| SUPERFAMILY | SSF56507 | Methionine synthase activation domain-like | IPR037010 | Vitamin B12-dependent methionine synthase, activation domain superfamily | 909 | 1233 | 1.07E-126 |
| FunFam | G3DSA:3.20.20.20:FF:000002 | Methionine synthase | - | - | 353 | 649 | 0.0 |
| SMART | SM01018 | B12_binding_2_2 | IPR003759 | Cobalamin (vitamin B12)-binding module, cap domain | 662 | 745 | 7.7E-40 |
| Gene3D | G3DSA:3.20.20.330 | - | IPR036589 | Homocysteine-binding domain superfamily | 9 | 345 | 6.0E-125 |
| SUPERFAMILY | SSF51717 | Dihydropteroate synthetase-like | IPR011005 | Dihydropteroate synthase-like | 363 | 636 | 2.22E-87 |
| SUPERFAMILY | SSF52242 | Cobalamin (vitamin B12)-binding domain | IPR036724 | Cobalamin-binding domain superfamily | 748 | 900 | 3.01E-44 |
| PIRSF | PIRSF000381 | Met_synth_MetH | IPR011822 | Cobalamin-dependent methionine synthase | 8 | 1203 | 0.0 |
| SUPERFAMILY | SSF82282 | Homocysteine S-methyltransferase | IPR036589 | Homocysteine-binding domain superfamily | 15 | 406 | 1.31E-116 |
| Gene3D | G3DSA:3.20.20.20 | - | IPR011005 | Dihydropteroate synthase-like | 353 | 650 | 0.0 |
| Gene3D | G3DSA:3.40.50.280 | - | - | - | 750 | 902 | 1.2E-57 |
| Gene3D | G3DSA:3.10.196.10 | - | IPR037010 | Vitamin B12-dependent methionine synthase, activation domain superfamily | 912 | 1232 | 0.0 |
| Gene3D | G3DSA:1.10.288.10 | - | - | - | 944 | 1101 | 0.0 |
| FunFam | G3DSA:3.40.50.280:FF:000001 | Methionine synthase | - | - | 750 | 902 | 6.4E-77 |
| NCBIfam | TIGR02082 | JCVI: methionine synthase | IPR011822 | Cobalamin-dependent methionine synthase | 20 | 1200 | 0.0 |
| FunFam | G3DSA:1.10.1240.10:FF:000001 | Methionine synthase | - | - | 651 | 745 | 7.5E-45 |
| Pfam | PF00809 | Pterin binding enzyme | IPR000489 | Pterin-binding domain | 367 | 605 | 2.2E-56 |
| Pfam | PF02574 | Homocysteine S-methyltransferase | IPR003726 | Homocysteine-binding domain | 24 | 332 | 4.8E-79 |
| Pfam | PF02607 | B12 binding domain | IPR003759 | Cobalamin (vitamin B12)-binding module, cap domain | 664 | 737 | 1.8E-24 |
| FunFam | G3DSA:3.20.20.330:FF:000001 | Methionine synthase | - | - | 9 | 345 | 0.0 |
| SUPERFAMILY | SSF47644 | Methionine synthase domain | IPR036594 | Methionine synthase domain | 657 | 744 | 3.66E-28 |
| CDD | cd02069 | methionine_synthase_B12_BD | IPR033706 | Methionine synthase, B12-binding domain | 664 | 878 | 1.23798E-125 |
| Pfam | PF02310 | B12 binding domain | IPR006158 | Cobalamin (vitamin B12)-binding domain | 754 | 847 | 2.5E-19 |
| Pfam | PF02965 | Vitamin B12 dependent methionine synthase, activation domain | IPR004223 | Vitamin B12-dependent methionine synthase, activation domain | 945 | 1216 | 1.5E-124 |
| CDD | cd00740 | MeTr | - | - | 363 | 619 | 3.05299E-125 |
| Gene3D | G3DSA:1.10.1240.10 | Methionine synthase domain | IPR036594 | Methionine synthase domain | 651 | 745 | 5.9E-38 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.