Pseudomonas protegens Pf-5, PFL_5445 (lipA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0051536 iron-sulfur cluster binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF04055
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009107 lipoate biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF005963
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016992 lipoate synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF005963
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF005963
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF04055
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Pathways

Database Xref Pathway Version Evidence PMID
MetaCyc lipoate biosynthesis and incorporation III (Bacillus) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc lipoate biosynthesis and incorporation (yeast) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG pfl01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pfl00785 Lipoic acid metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PIRSF PIRSF005963 Lipoyl_synth IPR003698 Lipoyl synthase 4 337 8.8E-130
SMART SM00729 MiaB IPR006638 Elp3/MiaA/NifB-like, radical SAM core domain 100 306 9.9E-16
PANTHER PTHR10949 LIPOYL SYNTHASE IPR003698 Lipoyl synthase 49 331 1.5E-115
SFLD SFLDG01058 lipoyl synthase like - - 49 332 0.0
Pfam PF04055 Radical SAM superfamily IPR007197 Radical SAM 107 266 7.6E-14
SFLD SFLDF00271 lipoyl synthase IPR003698 Lipoyl synthase 49 332 0.0
Hamap MF_00206 Lipoyl synthase [lipA]. IPR003698 Lipoyl synthase 52 340 153.320953
NCBIfam TIGR00510 JCVI: lipoyl synthase IPR003698 Lipoyl synthase 49 330 6.4E-129
Pfam PF16881 N-terminal domain of lipoyl synthase of Radical_SAM family IPR031691 Lipoyl synthase, N-terminal 53 89 2.4E-7
SUPERFAMILY SSF102114 Radical SAM enzymes - - 66 333 5.76E-69
Gene3D G3DSA:3.20.20.70 Aldolase class I IPR013785 Aldolase-type TIM barrel 97 309 4.0E-20
FunFam G3DSA:3.20.20.70:FF:000023 Lipoyl synthase - - 97 308 1.8E-119

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.