Pseudomonas aeruginosa AZPAE15017, NT33_RS12945

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa AZPAE15017
GCF_000793005.1|latest
Locus Tag
NT33_RS12945
Name
Replicon contig_7
Genomic location 602160 - 603593 (- strand)

Cross-References

RefSeq WP_033968981.1
GI 730279835
NCBI Locus Tag NT33_RS12945

Product

Feature Type CDS
Coding Frame 1
Product Name
multidrug transporter
Synonyms
Evidence for Translation
Charge (pH 7) 14.31
Kyte-Doolittle Hydrophobicity Value 0.642
Molecular Weight (kDa) 50.8
Isoelectric Point (pI) 10.15

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
PmpM PmpM is a multidrug efflux pump belonging to the MATE family of Pseudomonas aeruginosa. PmpM is an H+ drug antiporter and is the first reported case of an H+ coupled efflux pump in the MATE family. PmpM confers resistance to fluoroquinolones, fradiomycin, benzalkonium chloride, chlorhexidine gluconate, ethidium bromide, tetraphenylphosphonium chloride (TPPCl), and rhodamine 6G. [PMID:14679249] ARO:3004077 protein homolog model Strict 919.8 99.37 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001295 (965 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: NT33_RS12945

Human Homologs

Ensembl 110, assembly GRCh38.p14
solute carrier family 47 member 1 [Source:HGNC Symbol;Acc:HGNC:25588]
E-value: 2.0e-10
Percent Identity: 26.5

References

No references are associated with this feature.