Pseudomonas aeruginosa DK2, PADK2_28540

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004673 protein histidine kinase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02966
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0016310 phosphorylation
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00344
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0000160 phosphorelay signal transduction system
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF11808
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0007165 signal transduction
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00388
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0016020 membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02966
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016772 transferase activity, transferring phosphorus-containing groups
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00344
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0000155 phosphorelay sensor kinase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF11808
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006355 regulation of transcription, DNA-templated
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00989
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004721 phosphoprotein phosphatase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF11808
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Two-component regulatory systems Other DK2 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pdk02020 Two-component system 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF47384 Homodimeric domain of signal transducing histidine kinase IPR036097 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily 191 272 7.46E-22
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 389 407 1.2E-11
CDD cd16952 HATPase_EcPhoR-like - - 322 429 2.41837E-69
SUPERFAMILY SSF55874 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase IPR036890 Histidine kinase/HSP90-like ATPase superfamily 261 425 3.8E-40
Pfam PF11808 Phosphate regulon sensor protein PhoR IPR021766 Phosphate regulon sensor protein PhoR 5 90 4.6E-28
FunFam G3DSA:1.10.287.130:FF:000001 Two-component sensor histidine kinase - - 201 273 2.2E-25
Gene3D G3DSA:3.30.565.10 - IPR036890 Histidine kinase/HSP90-like ATPase superfamily 276 430 6.3E-36
Pfam PF00512 His Kinase A (phospho-acceptor) domain IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 205 271 9.8E-19
Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IPR003594 Histidine kinase/HSP90-like ATPase 318 426 1.1E-24
CDD cd00082 HisKA IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 203 258 1.12671E-13
SUPERFAMILY SSF55785 PYP-like sensor domain (PAS domain) IPR035965 PAS domain superfamily 109 204 1.1E-7
SMART SM00091 pas_2 IPR000014 PAS domain 98 166 6.6E-5
FunFam G3DSA:3.30.450.20:FF:000076 Phosphate regulon sensor histidine kinase PhoR - - 82 200 1.3E-71
CDD cd00130 PAS IPR000014 PAS domain 107 215 2.52868E-5
FunFam G3DSA:3.30.565.10:FF:000032 Phosphate regulon sensor histidine kinase PhoR - - 278 432 4.8E-62
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 413 426 1.2E-11
Coils Coil Coil - - 246 266 -
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 354 368 1.2E-11
PANTHER PTHR45453 PHOSPHATE REGULON SENSOR PROTEIN PHOR - - 5 432 0.0
NCBIfam TIGR02966 JCVI: phosphate regulon sensor histidine kinase PhoR IPR014310 Signal transduction histidine kinase, phosphate regulon sensor PhoR 94 425 0.0
Gene3D G3DSA:3.30.450.20 PAS domain - - 104 198 4.8E-8
Pfam PF00989 PAS fold IPR013767 PAS fold 98 152 1.7E-5
Gene3D G3DSA:1.10.287.130 - - - 199 271 1.6E-21
PRINTS PR00344 Bacterial sensor protein C-terminal signature IPR004358 Signal transduction histidine kinase-related protein, C-terminal 372 382 1.2E-11
SMART SM00388 HisKA_10 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 205 272 4.4E-21
SMART SM00387 HKATPase_4 IPR003594 Histidine kinase/HSP90-like ATPase 317 429 2.4E-33

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.