Pseudomonas aeruginosa PA7, PSPA7_1346 (guaB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006164 purine nucleotide biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01964
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd00381
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003938 IMP dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01964
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other PA7 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pap01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pap00230 Purine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pap01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF00571 CBS domain IPR000644 CBS domain 148 200 1.4E-5
SMART SM01240 IMPDH_2 - - 7 475 0.0
PIRSF PIRSF000130 IMPDH IPR005990 Inosine-5'-monophosphate dehydrogenase 1 489 0.0
NCBIfam TIGR01302 JCVI: IMP dehydrogenase IPR005990 Inosine-5'-monophosphate dehydrogenase 8 456 0.0
Pfam PF00571 CBS domain IPR000644 CBS domain 95 139 3.6E-10
Gene3D G3DSA:3.20.20.70 Aldolase class I IPR013785 Aldolase-type TIM barrel 2 488 0.0
CDD cd00381 IMPDH IPR001093 IMP dehydrogenase/GMP reductase 8 464 0.0
PANTHER PTHR11911 INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED IPR005990 Inosine-5'-monophosphate dehydrogenase 5 483 0.0
Pfam PF00478 IMP dehydrogenase / GMP reductase domain IPR001093 IMP dehydrogenase/GMP reductase 8 475 0.0
SMART SM00116 cbs_1 IPR000644 CBS domain 96 143 7.1E-11
SMART SM00116 cbs_1 IPR000644 CBS domain 157 205 6.7E-4
SUPERFAMILY SSF51412 Inosine monophosphate dehydrogenase (IMPDH) - - 2 479 3.53E-127
Hamap MF_01964 Inosine-5'-monophosphate dehydrogenase [guaB]. IPR005990 Inosine-5'-monophosphate dehydrogenase 8 488 83.89801
CDD cd04601 CBS_pair_IMPDH - - 94 202 5.56047E-47
SUPERFAMILY SSF54631 CBS-domain pair IPR046342 CBS domain superfamily 94 202 7.07E-26
FunFam G3DSA:3.20.20.70:FF:000003 GMP reductase - - 1 488 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.