Pseudomonas aeruginosa PA7, PSPA7_1113 (lipA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0009107 lipoate biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00510
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF04055
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0051536 iron-sulfur cluster binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF04055
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016992 lipoate synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00510
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00510
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PA7 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pap01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pap00785 Lipoic acid metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc lipoate biosynthesis and incorporation III (Bacillus) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
MetaCyc lipoate biosynthesis and incorporation (yeast) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF04055 Radical SAM superfamily IPR007197 Radical SAM 93 252 6.9E-15
Hamap MF_00206 Lipoyl synthase [lipA]. IPR003698 Lipoyl synthase 1 323 154.660355
SMART SM00729 MiaB IPR006638 Elp3/MiaA/NifB-like, radical SAM core domain 86 295 4.2E-14
Pfam PF16881 N-terminal domain of lipoyl synthase of Radical_SAM family IPR031691 Lipoyl synthase, N-terminal 39 75 2.1E-7
PANTHER PTHR10949 LIPOYL SYNTHASE IPR003698 Lipoyl synthase 36 318 3.2E-115
SFLD SFLDG01058 lipoyl synthase like - - 35 320 0.0
Gene3D G3DSA:3.20.20.70 Aldolase class I IPR013785 Aldolase-type TIM barrel 83 302 6.8E-20
SFLD SFLDF00271 lipoyl synthase IPR003698 Lipoyl synthase 35 320 0.0
PIRSF PIRSF005963 Lipoyl_synth IPR003698 Lipoyl synthase 7 323 5.3E-128
NCBIfam TIGR00510 JCVI: lipoyl synthase IPR003698 Lipoyl synthase 34 317 1.8E-127
SUPERFAMILY SSF102114 Radical SAM enzymes - - 52 318 7.06E-68
FunFam G3DSA:3.20.20.70:FF:000023 Lipoyl synthase - - 83 294 3.1E-119
CDD cd01335 Radical_SAM - - 93 268 2.67774E-7

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.