Pseudomonas aeruginosa UCBPP-PA14, PA14_44660 (ligA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Molecular Function | GO:0003911 | DNA ligase (NAD+) activity |
Inferred from Sequence Model
Term mapped from: InterPro:PF03120
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0006260 | DNA replication |
Inferred from Sequence Model
Term mapped from: InterPro:PF03120
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0006281 | DNA repair |
Inferred from Sequence Model
Term mapped from: InterPro:PF03120
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Functional Classifications Manually Assigned by PseudoCAP
|
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| KEGG | pau03030 | DNA replication | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | pau03410 | Base excision repair | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | pau03430 | Mismatch repair | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | pau03420 | Nucleotide excision repair | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| Pfam | PF03120 | NAD-dependent DNA ligase OB-fold domain | IPR004150 | NAD-dependent DNA ligase, OB-fold | 334 | 410 | 6.7E-35 |
| CDD | cd17748 | BRCT_DNA_ligase_like | - | - | 716 | 786 | 2.33857E-24 |
| Gene3D | G3DSA:2.40.50.140 | - | IPR012340 | Nucleic acid-binding, OB-fold | 329 | 402 | 3.3E-33 |
| Gene3D | G3DSA:1.10.287.610 | Helix hairpin bin | - | - | 1 | 67 | 1.3E-28 |
| SUPERFAMILY | SSF56091 | DNA ligase/mRNA capping enzyme, catalytic domain | - | - | 5 | 329 | 2.34E-118 |
| PIRSF | PIRSF001604 | LigA | IPR001679 | NAD-dependent DNA ligase | 620 | 792 | 2.3E-31 |
| Coils | Coil | Coil | - | - | 794 | 794 | - |
| Pfam | PF12826 | Helix-hairpin-helix motif | IPR041663 | DisA/LigA, helix-hairpin-helix motif | 632 | 687 | 2.4E-8 |
| Gene3D | G3DSA:1.10.150.20 | - | - | - | 624 | 701 | 1.3E-11 |
| FunFam | G3DSA:3.30.470.30:FF:000001 | DNA ligase | - | - | 68 | 327 | 4.0E-107 |
| NCBIfam | TIGR00575 | JCVI: DNA ligase (NAD(+)) LigA | IPR001679 | NAD-dependent DNA ligase | 14 | 617 | 0.0 |
| Pfam | PF03119 | NAD-dependent DNA ligase C4 zinc finger domain | IPR004149 | Zinc-finger, NAD-dependent DNA ligase C4-type | 419 | 458 | 1.4E-13 |
| CDD | cd00114 | LIGANc | IPR013839 | NAD-dependent DNA ligase, adenylation | 9 | 329 | 0.0 |
| Gene3D | G3DSA:6.20.10.30 | - | - | - | 403 | 453 | 2.4E-13 |
| SMART | SM00532 | ligaN3 | IPR013840 | NAD-dependent DNA ligase, N-terminal | 6 | 472 | 0.0 |
| SUPERFAMILY | SSF47781 | RuvA domain 2-like | IPR010994 | RuvA domain 2-like | 618 | 704 | 7.41E-14 |
| FunFam | G3DSA:1.10.287.610:FF:000002 | DNA ligase | - | - | 2 | 67 | 3.0E-29 |
| FunFam | G3DSA:1.10.150.20:FF:000006 | DNA ligase | - | - | 530 | 609 | 3.4E-25 |
| Gene3D | G3DSA:1.10.150.20 | - | - | - | 454 | 528 | 3.0E-28 |
| Pfam | PF00533 | BRCA1 C Terminus (BRCT) domain | IPR001357 | BRCT domain | 713 | 787 | 2.2E-11 |
| PANTHER | PTHR23389 | CHROMOSOME TRANSMISSION FIDELITY FACTOR 18 | - | - | 16 | 770 | 2.0E-55 |
| PIRSF | PIRSF001604 | LigA | IPR001679 | NAD-dependent DNA ligase | 1 | 622 | 0.0 |
| FunFam | G3DSA:1.10.150.20:FF:000007 | DNA ligase | - | - | 454 | 529 | 3.4E-30 |
| Gene3D | G3DSA:1.10.150.20 | - | - | - | 529 | 611 | 1.9E-24 |
| Pfam | PF01653 | NAD-dependent DNA ligase adenylation domain | IPR013839 | NAD-dependent DNA ligase, adenylation | 7 | 330 | 6.2E-124 |
| SUPERFAMILY | SSF47781 | RuvA domain 2-like | IPR010994 | RuvA domain 2-like | 416 | 603 | 1.04E-52 |
| Gene3D | G3DSA:3.40.50.10190 | BRCT domain | IPR036420 | BRCT domain superfamily | 702 | 788 | 2.0E-23 |
| Pfam | PF12826 | Helix-hairpin-helix motif | IPR041663 | DisA/LigA, helix-hairpin-helix motif | 534 | 597 | 7.3E-21 |
| Hamap | MF_01588 | DNA ligase [ligA]. | IPR001679 | NAD-dependent DNA ligase | 5 | 787 | 52.91758 |
| SMART | SM00292 | BRCT_7 | IPR001357 | BRCT domain | 713 | 790 | 6.3E-9 |
| Gene3D | G3DSA:3.30.470.30 | DNA ligase/mRNA capping enzyme | - | - | 68 | 327 | 2.9E-98 |
| FunFam | G3DSA:3.40.50.10190:FF:000069 | DNA ligase | - | - | 706 | 789 | 8.8E-42 |
| SUPERFAMILY | SSF52113 | BRCT domain | IPR036420 | BRCT domain superfamily | 714 | 788 | 5.23E-17 |
| FunFam | G3DSA:2.40.50.140:FF:000012 | DNA ligase | - | - | 329 | 402 | 9.4E-35 |
| SUPERFAMILY | SSF50249 | Nucleic acid-binding proteins | IPR012340 | Nucleic acid-binding, OB-fold | 330 | 412 | 3.26E-28 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.