Pseudomonas aeruginosa UCBPP-PA14, PA14_40670 (metH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0008705 methionine synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02965
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0046872 metal ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02310
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009086 methionine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02965
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0044237 cellular metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.20.20.20
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0031419 cobalamin binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02310
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008270 zinc ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000381
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0042558 pteridine-containing compound metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00809
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc L-methionine biosynthesis IV (archaea) InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG pau00670 One carbon pool by folate 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00270 Cysteine and methionine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc folate transformations II InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG pau00450 Selenocompound metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
MetaCyc folate transformations I InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:1.10.288.10 - - - 944 1101 0.0
Gene3D G3DSA:1.10.1240.10 Methionine synthase domain IPR036594 Methionine synthase domain 651 745 5.9E-38
Pfam PF02574 Homocysteine S-methyltransferase IPR003726 Homocysteine-binding domain 24 332 1.1E-78
SUPERFAMILY SSF82282 Homocysteine S-methyltransferase IPR036589 Homocysteine-binding domain superfamily 15 406 2.75E-116
SMART SM01018 B12_binding_2_2 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain 662 745 7.7E-40
CDD cd02069 methionine_synthase_B12_BD IPR033706 Methionine synthase, B12-binding domain 664 878 1.13871E-125
FunFam G3DSA:3.40.50.280:FF:000001 Methionine synthase - - 750 902 6.4E-77
Pfam PF02965 Vitamin B12 dependent methionine synthase, activation domain IPR004223 Vitamin B12-dependent methionine synthase, activation domain 945 1216 1.5E-124
Gene3D G3DSA:3.20.20.330 - IPR036589 Homocysteine-binding domain superfamily 9 345 1.1E-124
Pfam PF02310 B12 binding domain IPR006158 Cobalamin (vitamin B12)-binding domain 754 847 2.5E-19
SUPERFAMILY SSF47644 Methionine synthase domain IPR036594 Methionine synthase domain 657 744 3.66E-28
Gene3D G3DSA:3.10.196.10 - IPR037010 Vitamin B12-dependent methionine synthase, activation domain superfamily 912 1232 0.0
SUPERFAMILY SSF52242 Cobalamin (vitamin B12)-binding domain IPR036724 Cobalamin-binding domain superfamily 748 900 3.01E-44
Gene3D G3DSA:3.20.20.20 - IPR011005 Dihydropteroate synthase-like 353 650 0.0
Pfam PF00809 Pterin binding enzyme IPR000489 Pterin-binding domain 367 605 2.3E-56
NCBIfam TIGR02082 JCVI: methionine synthase IPR011822 Cobalamin-dependent methionine synthase 20 1200 0.0
SUPERFAMILY SSF51717 Dihydropteroate synthetase-like IPR011005 Dihydropteroate synthase-like 363 636 1.83E-87
Pfam PF02607 B12 binding domain IPR003759 Cobalamin (vitamin B12)-binding module, cap domain 664 737 1.8E-24
Gene3D G3DSA:3.40.50.280 - - - 750 902 1.2E-57
PANTHER PTHR45833 METHIONINE SYNTHASE - - 13 1232 0.0
FunFam G3DSA:3.20.20.20:FF:000002 Methionine synthase - - 353 649 0.0
FunFam G3DSA:3.20.20.330:FF:000001 Methionine synthase - - 9 345 0.0
FunFam G3DSA:1.10.1240.10:FF:000001 Methionine synthase - - 651 745 7.5E-45
PIRSF PIRSF000381 Met_synth_MetH IPR011822 Cobalamin-dependent methionine synthase 8 1203 0.0
SUPERFAMILY SSF56507 Methionine synthase activation domain-like IPR037010 Vitamin B12-dependent methionine synthase, activation domain superfamily 909 1233 1.07E-126
CDD cd00740 MeTr - - 363 619 7.93495E-126

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.