Pseudomonas aeruginosa PAO1, PA5372 (betA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0050896 response to stimulus
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0019285 glycine betaine biosynthetic process from choline
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01810
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00732
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0050660 flavin adenine dinucleotide binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR11552
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008812 choline dehydrogenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01810
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Adaptation, Protection Other PAO1 genes in this class
Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCAP Glycine, serine and threonine metabolism ECO:0000037
not_recorded
PseudoCyc P542-PWY choline-O-sulfate degradation 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc CHOLINE-BETAINE-ANA-PWY choline degradation I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00260 Glycine, serine and threonine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.30.560.10 Glucose Oxidase, domain 3 - - 45 474 0.0
Pfam PF05199 GMC oxidoreductase IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal 395 529 3.3E-42
SUPERFAMILY SSF54373 FAD-linked reductases, C-terminal domain - - 297 479 6.08E-64
NCBIfam TIGR01810 JCVI: choline dehydrogenase IPR011533 Oxygen-dependent choline dehydrogenase 6 539 0.0
Hamap MF_00750 Oxygen-dependent choline dehydrogenase [betA]. IPR011533 Oxygen-dependent choline dehydrogenase 3 556 64.893791
PIRSF PIRSF000137 Alcohol_oxidase IPR012132 Glucose-methanol-choline oxidoreductase 1 540 0.0
SUPERFAMILY SSF51905 FAD/NAD(P)-binding domain IPR036188 FAD/NAD(P)-binding domain superfamily 1 537 1.2E-88
Pfam PF00732 GMC oxidoreductase IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal 5 302 1.2E-95
Gene3D G3DSA:3.50.50.60 - IPR036188 FAD/NAD(P)-binding domain superfamily 6 527 0.0
PANTHER PTHR11552 GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE IPR012132 Glucose-methanol-choline oxidoreductase 4 541 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.