Pseudomonas aeruginosa PAO1, PA4843 (gcbA)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0009975	cyclase activity
Molecular Function	GO:0052621	diguanylate cyclase activity	EXP Inferred from Experiment	ECO:0000269 experimental evidence used in manual assertion	24603766	Reviewed by curator
Biological Process	GO:1902065	response to L-glutamate	IMP Inferred from Mutant Phenotype	ECO:0000016 loss-of-function mutant phenotype evidence	25331436	Reviewed by curator
Biological Process	GO:1900233	positive regulation of single-species biofilm formation on inanimate substrate	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	24603766	Reviewed by curator
Biological Process	GO:1902201	negative regulation of bacterial-type flagellum-dependent cell motility	ISS Inferred from Sequence or Structural Similarity Term mapped from: UniProtKB:Q3KIN9	ECO:0000250 sequence similarity evidence used in manual assertion	24891445	Reviewed by curator
Molecular Function	GO:0052621	diguanylate cyclase activity	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	24603766	Reviewed by curator
Biological Process	GO:1900189	positive regulation of cell adhesion involved in single-species biofilm formation	ISS Inferred from Sequence or Structural Similarity Term mapped from: UniProtKB:Q3KIN9	ECO:0000250 sequence similarity evidence used in manual assertion	24891445	Reviewed by curator
Molecular Function	GO:0052621	diguanylate cyclase activity	IDA Inferred from Direct Assay	ECO:0000005 enzyme assay evidence	24891445	Reviewed by curator
Biological Process	GO:0000160	phosphorelay signal transduction system	ISM Inferred from Sequence Model Term mapped from: InterPro:PF00072	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Two-component regulatory systems Other PAO1 genes in this class Transcriptional regulators Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
PseudoCAP		Two-component System		ECO:0000037 not_recorded

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Gene3D	G3DSA:3.30.70.270	-	IPR043128	Reverse transcriptase/Diguanylate cyclase domain	376	540	8.7E-53
SUPERFAMILY	SSF55073	Nucleotide cyclase	IPR029787	Nucleotide cyclase	382	539	5.49E-48
FunFam	G3DSA:3.40.50.2300:FF:000346	Diguanylate cyclase response regulator	-	-	247	375	3.8E-63
SMART	SM00448	REC_2	IPR001789	Signal transduction response regulator, receiver domain	250	363	2.8E-26
PANTHER	PTHR45138	REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM	-	-	64	539	3.8E-93
SUPERFAMILY	SSF52172	CheY-like	IPR011006	CheY-like superfamily	246	378	7.26E-30
Pfam	PF00072	Response regulator receiver domain	IPR001789	Signal transduction response regulator, receiver domain	252	363	1.4E-21
Coils	Coil	Coil	-	-	48	68	-
SMART	SM00267	duf1_3	IPR000160	GGDEF domain	366	537	2.6E-55
Gene3D	G3DSA:3.40.50.2300	-	-	-	245	375	3.5E-27
SUPERFAMILY	SSF52172	CheY-like	IPR011006	CheY-like superfamily	134	243	3.22E-5
NCBIfam	TIGR00254	JCVI: diguanylate cyclase (GGDEF) domain	IPR000160	GGDEF domain	374	536	7.1E-46
FunFam	G3DSA:3.30.70.270:FF:000001	Diguanylate cyclase domain protein	-	-	372	538	8.4E-49
Pfam	PF00990	Diguanylate cyclase, GGDEF domain	IPR000160	GGDEF domain	379	533	2.9E-41
CDD	cd01949	GGDEF	IPR000160	GGDEF domain	379	534	8.25412E-59
CDD	cd00156	REC	-	-	253	353	5.43678E-23
Gene3D	G3DSA:3.40.50.2300	-	-	-	112	243	1.0E-5

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.