Pseudomonas aeruginosa PAO1, PA4756 (carB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 6402363 Reviewed by curator
Biological Process GO:0006536 glutamate metabolic process
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 6402363 Reviewed by curator
Biological Process GO:0071230 cellular response to amino acid stimulus
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 8169201 Reviewed by curator
Biological Process GO:0006807 nitrogen compound metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01369
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005524 ATP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02786
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class
Nucleotide biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc PWY0-162 superpathway of pyrimidine ribonucleotides de novo biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00240 Pyrimidine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc ARGSYNBSUB-PWY L-arginine biosynthesis II (acetyl cycle) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00250 Alanine, aspartate and glutamate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Glutamate metabolism ECO:0000037
not_recorded
PseudoCyc PWY-5686 UMP biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Arginine and proline metabolism ECO:0000037
not_recorded
PseudoCyc PRPP-PWY superpathway of histidine, purine, and pyrimidine biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Pyrimidine metabolism ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain 297 326 4.0E-66
Hamap MF_01210_B Carbamoyl-phosphate synthase large chain [carB]. IPR006275 Carbamoyl-phosphate synthase, large subunit 1 1062 13.125657
SUPERFAMILY SSF56059 Glutathione synthetase ATP-binding domain-like - - 128 401 1.94E-109
Pfam PF02142 MGS-like domain IPR011607 Methylglyoxal synthase-like domain 958 1041 2.0E-19
Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain 673 875 1.1E-32
Gene3D G3DSA:3.40.50.1380 - IPR036914 Methylglyoxal synthase-like domain superfamily 936 1072 1.6E-42
Gene3D G3DSA:1.10.1030.10 - IPR036897 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily 404 553 1.2E-54
NCBIfam TIGR01369 JCVI: carbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit IPR006275 Carbamoyl-phosphate synthase, large subunit 2 1053 0.0
FunFam G3DSA:3.40.50.1380:FF:000004 Carbamoyl-phosphate synthase large chain - - 936 1072 2.5E-63
FunFam G3DSA:3.30.470.20:FF:000013 Carbamoyl-phosphate synthase large chain - - 665 935 0.0
Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain 128 334 1.6E-72
SUPERFAMILY SSF52440 PreATP-grasp domain IPR016185 Pre-ATP-grasp domain superfamily 1 127 2.01E-49
SUPERFAMILY SSF52440 PreATP-grasp domain IPR016185 Pre-ATP-grasp domain superfamily 557 675 2.3E-49
PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain 239 256 4.0E-66
SUPERFAMILY SSF52335 Methylglyoxal synthase-like IPR036914 Methylglyoxal synthase-like domain superfamily 938 1069 1.01E-39
Pfam PF02787 Carbamoyl-phosphate synthetase large chain, oligomerisation domain IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain 427 505 1.8E-25
SUPERFAMILY SSF48108 Carbamoyl phosphate synthetase, large subunit connection domain IPR036897 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily 396 554 6.28E-53
PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain 168 180 4.0E-66
FunFam G3DSA:3.40.50.20:FF:000003 Carbamoyl-phosphate synthase large chain - - 554 662 1.2E-63
Gene3D G3DSA:3.30.470.20 - - - 665 935 8.0E-120
FunFam G3DSA:3.30.470.20:FF:000007 Carbamoyl-phosphate synthase large chain - - 119 403 0.0
FunFam G3DSA:1.10.1030.10:FF:000002 Carbamoyl-phosphate synthase large chain - - 405 553 1.7E-58
CDD cd01424 MGS_CPS_II IPR033937 Carbamoyl-phosphate synthase large chain, methylglyoxal synthase-like domain 942 1051 9.32562E-50
FunFam G3DSA:3.30.1490.20:FF:000001 Carbamoyl-phosphate synthase large chain - - 686 755 1.3E-26
Gene3D G3DSA:3.40.50.20 - - - 1 116 8.7E-49
Gene3D G3DSA:3.40.50.20 - - - 554 662 5.6E-51
SMART SM01096 CPSase_L_D3_2 IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain 424 547 6.4E-75
PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain 204 223 4.0E-66
PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain 380 398 4.0E-66
PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain 19 33 4.0E-66
SUPERFAMILY SSF56059 Glutathione synthetase ATP-binding domain-like - - 673 933 6.72E-102
SMART SM00851 MGS_2a IPR011607 Methylglyoxal synthase-like domain 955 1041 2.7E-32
Gene3D G3DSA:3.30.470.20 - - - 119 403 0.0
Hamap MF_01210_A Carbamoyl-phosphate synthase large chain [carB]. IPR006275 Carbamoyl-phosphate synthase, large subunit 5 1067 13.404976
PANTHER PTHR11405 CARBAMOYLTRANSFERASE FAMILY MEMBER - - 6 1061 0.0
FunFam G3DSA:3.40.50.20:FF:000001 Carbamoyl-phosphate synthase large chain - - 1 116 2.2E-54
PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain 48 58 4.0E-66

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.