Pseudomonas aeruginosa PAO1, PA4300 (tadC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4300
Name
tadC
Synonym: tadC
Replicon chromosome
Genomic location 4824121 - 4825032 (- strand)
Transposon Mutants 4 transposon mutants in PAO1

Cross-References

RefSeq NP_252990.1
GI 15599496
Affymetrix PA4300_at
DNASU PaCD00007865
Entrez 881553
GenBank AAG07688.1
INSDC AAG07688.1
NCBI Locus Tag PA4300
protein_id(GenBank) gb|AAG07688.1|AE004846_5|gnl|PseudoCAP|PA4300
TIGR NTL03PA04301
UniParc UPI00000C5CA5
UniProtKB Acc Q9HWA0
UniProtKB ID Q9HWA0_PSEAE
UniRef100 UniRef100_W0YW26
UniRef50 UniRef50_W0YW26
UniRef90 UniRef90_W0YW26

Product

Feature Type CDS
Coding Frame 1
Product Name
TadC
Product Name Confidence: Class 2
Synonyms TadC
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 9.39
Kyte-Doolittle Hydrophobicity Value 0.404
Molecular Weight (kDa) 33.6
Isoelectric Point (pI) 10.49

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 127 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003901 (427 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4300
Search term: tadC
Search term: TadC

Human Homologs

References

FppA, a novel Pseudomonas aeruginosa prepilin peptidase involved in assembly of type IVb pili.
de Bentzmann S, Aurouze M, Ball G, Filloux A
J Bacteriol 2006 Jul;188(13):4851-60
PubMed ID: 16788194
Mutation analysis of the flp operon in Actinobacillus actinomycetemcomitans.
Wang Y, Chen C
Gene 2005 May 23;351:61-71
PubMed ID: 15837433