Pseudomonas aeruginosa PAO1, PA3044 (rocsS2)

Annotation Updates

Date	Description	Acknowledgements
Aug 25, 2011	New product name: Two-component sensor RocS2. New gene name: rocsS2. New product name confidence: Class 1. New comment : Overexpression of rocS2 leads to the production of CupB and CupC fimbriae, as well as repression of the MexAB-OprM efflux pump. RocS2 can interact with three response regulators: RocA2 (PA3045), RocA1 (PA3948) and RocR (PA3947).. New comment : Functional studies in Pseudomonas aeruginosa PAK have shown that RocS2 is part of a signalling network that induces the expression of the cupB and cupC gene clusters, leading to the production and assembly of two distinct types of fimbriae on the cell surface and increases biofilm formation. Expression of rocS2 also represses the expression of the mexAB-oprM gene cluster, leading to increased sensitivity to ?-lactams and other antibiotics. This signalling network involves at least three response regulators: RocA1 (PA3948), RocA2 (PA3045) and RocR (PA3947). Genetic and bacterial two hybrid analyses have shown that RocS2 signals through all three response regulators.. New PubMed reference: 15659157. New PubMed reference: 21205015.	Allain Filloux, Imperial College London