Pseudomonas aeruginosa PAO1, PA2579 (kynA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004833 tryptophan 2,3-dioxygenase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 14592712 Reviewed by curator
Molecular Function GO:0046872 metal ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF140959
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0019441 tryptophan catabolic process to kynurenine
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR03036
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004833 tryptophan 2,3-dioxygenase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR03036
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0020037 heme binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF03301
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Putative enzymes Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCAP kynurenine pathway ECO:0000037
not_recorded
KEGG pae00380 Tryptophan metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF03301 Tryptophan 2,3-dioxygenase IPR004981 Tryptophan 2,3-dioxygenase 21 212 3.1E-42
FunFam G3DSA:1.20.58.480:FF:000001 Tryptophan 2,3-dioxygenase - - 29 288 5.5E-129
SUPERFAMILY SSF140959 Indolic compounds 2,3-dioxygenase-like IPR037217 Tryptophan/Indoleamine 2,3-dioxygenase-like 31 287 4.05E-100
NCBIfam TIGR03036 JCVI: tryptophan 2,3-dioxygenase IPR017485 Tryptophan 2,3-dioxygenase, bacterial 25 288 2.4E-128
Gene3D G3DSA:1.20.58.480 - - - 29 288 5.6E-97
PANTHER PTHR10138 TRYPTOPHAN 2,3-DIOXYGENASE IPR004981 Tryptophan 2,3-dioxygenase 191 288 1.9E-75
Hamap MF_01972 Tryptophan 2,3-dioxygenase [kynA]. IPR004981 Tryptophan 2,3-dioxygenase 25 288 40.526096

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.