Pseudomonas aeruginosa PAO1, PA1843 (metH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0008705 methionine synthase activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 11479715 Reviewed by curator
Biological Process GO:0044237 cellular metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.20.20.20
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0046872 metal ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF52242
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0042558 pteridine-containing compound metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00809
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0009086 methionine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02965
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008705 methionine synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02965
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008270 zinc ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000381
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0031419 cobalamin binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd02069
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00270 Cysteine and methionine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00450 Selenocompound metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00670 One carbon pool by folate 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Methionine metabolism ECO:0000037
not_recorded
PseudoCAP One carbon pool by folate ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PANTHER PTHR45833 METHIONINE SYNTHASE - - 13 1232 0.0
CDD cd00740 MeTr - - 363 619 7.93495E-126
Gene3D G3DSA:3.10.196.10 - IPR037010 Vitamin B12-dependent methionine synthase, activation domain superfamily 912 1232 0.0
SUPERFAMILY SSF56507 Methionine synthase activation domain-like IPR037010 Vitamin B12-dependent methionine synthase, activation domain superfamily 909 1233 1.07E-126
SUPERFAMILY SSF47644 Methionine synthase domain IPR036594 Methionine synthase domain 657 744 3.66E-28
Pfam PF02965 Vitamin B12 dependent methionine synthase, activation domain IPR004223 Vitamin B12-dependent methionine synthase, activation domain 945 1216 1.5E-124
SMART SM01018 B12_binding_2_2 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain 662 745 7.7E-40
CDD cd02069 methionine_synthase_B12_BD IPR033706 Methionine synthase, B12-binding domain 664 878 1.25098E-125
SUPERFAMILY SSF51717 Dihydropteroate synthetase-like IPR011005 Dihydropteroate synthase-like 363 636 1.83E-87
FunFam G3DSA:3.20.20.330:FF:000001 Methionine synthase - - 9 345 0.0
Gene3D G3DSA:1.10.288.10 - - - 944 1101 0.0
FunFam G3DSA:3.20.20.20:FF:000002 Methionine synthase - - 353 649 0.0
FunFam G3DSA:1.10.1240.10:FF:000001 Methionine synthase - - 651 745 7.5E-45
FunFam G3DSA:3.40.50.280:FF:000001 Methionine synthase - - 750 902 6.4E-77
Gene3D G3DSA:3.20.20.330 - IPR036589 Homocysteine-binding domain superfamily 9 345 6.0E-125
PIRSF PIRSF000381 Met_synth_MetH IPR011822 Cobalamin-dependent methionine synthase 8 1203 0.0
SUPERFAMILY SSF52242 Cobalamin (vitamin B12)-binding domain IPR036724 Cobalamin-binding domain superfamily 748 900 3.01E-44
SUPERFAMILY SSF82282 Homocysteine S-methyltransferase IPR036589 Homocysteine-binding domain superfamily 15 406 1.31E-116
Gene3D G3DSA:3.20.20.20 - IPR011005 Dihydropteroate synthase-like 353 650 0.0
Pfam PF02607 B12 binding domain IPR003759 Cobalamin (vitamin B12)-binding module, cap domain 664 737 1.8E-24
Gene3D G3DSA:3.40.50.280 - - - 750 902 1.2E-57
Pfam PF02310 B12 binding domain IPR006158 Cobalamin (vitamin B12)-binding domain 754 847 2.5E-19
Pfam PF00809 Pterin binding enzyme IPR000489 Pterin-binding domain 367 605 2.3E-56
Gene3D G3DSA:1.10.1240.10 Methionine synthase domain IPR036594 Methionine synthase domain 651 745 5.9E-38
NCBIfam TIGR02082 JCVI: methionine synthase IPR011822 Cobalamin-dependent methionine synthase 20 1200 0.0
Pfam PF02574 Homocysteine S-methyltransferase IPR003726 Homocysteine-binding domain 24 332 4.8E-79

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.