Pseudomonas aeruginosa PAO1, PA1802 (clpX)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1802
Name
clpX
Replicon chromosome
Genomic location 1954815 - 1956095 (+ strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250493.1
GI 15596999
Affymetrix PA1802_clpX_at
Entrez 878307
GenBank AAG05191.1
INSDC AAG05191.1
NCBI Locus Tag PA1802
protein_id(GenBank) gb|AAG05191.1|AE004606_5|gnl|PseudoCAP|PA1802
TIGR NTL03PA01803
UniParc UPI0000127B7D
UniProtKB Acc Q9I2U0
UniProtKB ID CLPX_PSEAE
UniRef100 UniRef100_A6V718
UniRef50 UniRef50_Q48KY9
UniRef90 UniRef90_Q48KY9

Product

Feature Type CDS
Coding Frame 1
Product Name
ClpX
Product Name Confidence: Class 2
Synonyms heat shock protein
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -12.22
Kyte-Doolittle Hydrophobicity Value -0.291
Molecular Weight (kDa) 47.0
Isoelectric Point (pI) 4.84

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 610 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003595 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1802
Search term: clpX
Search term: ClpX

Human Homologs

Ensembl 110, assembly GRCh38.p14
caseinolytic mitochondrial matrix peptidase chaperone subunit X [Source:HGNC Symbol;Acc:HGNC:2088]
E-value: 8.2e-88
Percent Identity: 44.7

References

The ClpX heat-shock protein of Escherichia coli, the ATP-dependent substrate specificity component of the ClpP-ClpX protease, is a novel molecular chaperone.
Wawrzynow A, Wojtkowiak D, Marszalek J, Banecki B, Jonsen M, Graves B, Georgopoulos C, Zylicz M
EMBO J 1995 May 1;14(9):1867-77
PubMed ID: 7743994
ClpXP proteases positively regulate alginate overexpression and mucoid conversion in Pseudomonas aeruginosa.
Qiu D, Eisinger VM, Head NE, Pier GB, Yu HD
Microbiology (Reading) 2008 Jul;154(Pt 7):2119-2130
PubMed ID: 18599839