Pseudomonas aeruginosa PAO1, PA1757 (thrH)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0009088	threonine biosynthetic process	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	10220164	Reviewed by curator
Molecular Function	GO:0000287	magnesium ion binding	ISS Inferred from Sequence or Structural Similarity Term mapped from: UniProtKB:P05041	ECO:0000250 sequence similarity evidence used in manual assertion	2251281	Reviewed by curator
Biological Process	GO:0009088	threonine biosynthetic process	IGI Inferred from Genetic Interaction	ECO:0000316 genetic interaction evidence used in manual assertion	10220164	Reviewed by curator
Biological Process	GO:0046654	tetrahydrofolate biosynthetic process	ISS Inferred from Sequence or Structural Similarity Term mapped from: UniProtKB:P05041	ECO:0000250 sequence similarity evidence used in manual assertion	16605270	Reviewed by curator
Molecular Function	GO:0043899	phosphoserine:homoserine phosphotransferase activity	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	14699121	Reviewed by curator
Molecular Function	GO:0004413	homoserine kinase activity	IGI Inferred from Genetic Interaction	ECO:0000316 genetic interaction evidence used in manual assertion	10220164	Reviewed by curator
Biological Process	GO:0006564	L-serine biosynthetic process	IGI Inferred from Genetic Interaction	ECO:0000316 genetic interaction evidence used in manual assertion	10220164	Reviewed by curator
Molecular Function	GO:0046820	4-amino-4-deoxychorismate synthase activity	ISS Inferred from Sequence or Structural Similarity Term mapped from: UniProtKB:P05041	ECO:0000250 sequence similarity evidence used in manual assertion	2251281	Reviewed by curator
Molecular Function	GO:0004647	phosphoserine phosphatase activity	IGI Inferred from Genetic Interaction	ECO:0000316 genetic interaction evidence used in manual assertion	10220164	Reviewed by curator

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae00260	Glycine, serine and threonine metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Glycine, serine and threonine metabolism		ECO:0000037 not_recorded
KEGG	pae01130	Biosynthesis of antibiotics	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	THRESYN-PWY	superpathway of L-threonine biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01120	Microbial metabolism in diverse environments	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01110	Biosynthesis of secondary metabolites	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01230	Biosynthesis of amino acids	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	HOMOSER-THRESYN-PWY	L-threonine biosynthesis	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae00680	Methane metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	P4-PWY	superpathway of L-lysine, L-threonine and L-methionine biosynthesis I	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Gene3D	G3DSA:3.40.50.1000	-	IPR023214	HAD superfamily	3	191	1.4E-90
Gene3D	G3DSA:3.90.1470.10	thrh gene product, domain 2	-	-	13	128	1.4E-90
NCBIfam	TIGR02137	JCVI: bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH	IPR011863	Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein	1	203	6.7E-125
PANTHER	PTHR43344	PHOSPHOSERINE PHOSPHATASE	-	-	32	173	8.5E-16
CDD	cd02607	HAD_ThrH_like	-	-	1	195	3.35766E-127
Pfam	PF12710	haloacid dehalogenase-like hydrolase	-	-	64	160	3.5E-9
SUPERFAMILY	SSF56784	HAD-like	IPR036412	HAD-like superfamily	2	191	9.53E-45

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.