Pseudomonas aeruginosa PAO1, PA1557 (ccoN2)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA1557
Name	ccoN2 Synonym: fixN Synonym: ccoN Synonym: cytN
Replicon	chromosome
Genomic location	1694852 - 1696279 (- strand)
Transposon Mutants	2 transposon mutants in PAO1
Transposon Mutants in orthologs	9 transposon mutants in orthologs

Cross-References

RefSeq	NP_250248.1
GI	15596754
Affymetrix	PA1557_at
Entrez	879347
GenBank	AAG04946.1
INSDC	AAG04946.1
NCBI Locus Tag	PA1557
protein_id(GenBank)	gb|AAG04946.1|AE004584_2|gnl|PseudoCAP|PA1557
TIGR	NTL03PA01558
UniParc	UPI00000C53DB
UniProtKB Acc	Q9I3G0
UniProtKB ID	Q9I3G0_PSEAE
UniRef100	UniRef100_Q9I3G0
UniRef50	UniRef50_Q9I3G0
UniRef90	UniRef90_Q9I3G0

Product

Feature Type	CDS
Coding Frame	1
Product Name	Cytochrome c oxidase, cbb3-type, CcoN subunit Product Name Confidence: Class 1
Synonyms	cytochrome c oxidase poly peptide I homolog (heme b/copper cytochrome c oxidase sub unit)
Evidence for Translation	Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7)	9.52
Kyte-Doolittle Hydrophobicity Value	0.588
Molecular Weight (kDa)	53.1
Isoelectric Point (pI)	9.26

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 271 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG001566 (1638 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA1557 Search term: ccoN2 Search term: Cytochrome c oxidase, cbb3-type, CcoN subunit

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen. Lewenza S, Gardy JL, Brinkman FS, Hancock RE Genome Res 2005 Feb;15(2):321-9 PubMed ID: 15687295

Genes for a microaerobically induced oxidase complex in Bradyrhizobium japonicum are essential for a nitrogen-fixing endosymbiosis. Preisig O, Anthamatten D, Hennecke H Proc Natl Acad Sci U S A 1993 Apr 15;90(8):3309-13 PubMed ID: 8386371

A homolog of the Rhizobium meliloti nitrogen fixation gene fixN is involved in the production of a microaerobically induced oxidase activity in the phytopathogenic bacterium Agrobacterium tumefaciens. Schlüter A, Rüberg S, Krämer M, Weidner S, Priefer UB Mol Gen Genet 1995 Apr 20;247(2):206-15 PubMed ID: 7753030

Structural and functional analysis of aa3-type and cbb3-type cytochrome c oxidases of Paracoccus denitrificans reveals significant differences in proton-pump design. de Gier JW, Schepper M, Reijnders WN, van Dyck SJ, Slotboom DJ, Warne A, Saraste M, Krab K, Finel M, Stouthamer AH, van Spanning RJ, van der Oost J Mol Microbiol 1996 Jun;20(6):1247-60 PubMed ID: 8809776