Pseudomonas aeruginosa PAO1, PA0680 (hxcV)

Annotation Updates

Date	Description	Acknowledgements
May 8, 2015	New gene name: hxcV. New product name: HxcV. New product name confidence: Class 1.	Rome Voulhoux, CNRS, Marseille, France
May 12, 2006	New structure feature: Manually-identified prepilin peptidase substrate (type IV) export signal (MSTRLSSRGFTLIE)	Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Jun 10, 2004	Annotation of gene previously described as probable type II secretion system protein (Class 3). New protein name: HxcV putative pseudopilin. New evidence reference (PubMed ID): 11985723. New homology added: 49% identical and 66% similar to GspI[Burkholderia pseudomallei]; 38% identical and 53% similar to XcpV[Pseudomonas alcaligenes]; 34% identical and 49% similar to XcpV[Pseudomonas aeruginosa]. New genomic context added: Ribosome binding site: GCCGACC from -15 to -9 (Kolaskar and Reddy rule for ATG: 18). New structure features: The leader peptide extends between residues 1 to 9, and includes the invariant glycine after which cleavage by the prepilin peptidase takes place. The new N-terminal is phenylalanine, and precedes 20 highly hydrophobic residues. New comments: Hxc proteins are involved in the secretion of alkaline phosphatase. hxc gene cluster is under phosphate regulation.Belongs to the GspI family (general secretory pathway).	Raymond C. Lo and Fiona S.L. Brinkman, Simon Fraser University, Canada (based on literature review);