Pseudomonas aeruginosa 2192, PA2G_05253

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa 2192
GCF_000152545.1|latest
Locus Tag
PA2G_05253
Name
Replicon chromosome
Genomic location 5863611 - 5865935 (+ strand)

Cross-References

RefSeq ZP_04937720.1
GI 254244398
NCBI Locus Tag PA2G_05253
UniProtKB Acc A3LK58
UniProtKB ID A3LK58_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
penicillin-binding protein 1B
Synonyms
Evidence for Translation
Charge (pH 7) 11.89
Kyte-Doolittle Hydrophobicity Value -0.291
Molecular Weight (kDa) 85.5
Isoelectric Point (pI) 9.57

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Ceftolozane DB09050 DrugBank 5.1.4 Q9X6W0 Penicillin-binding protein 1B 99.9 774 0.0e+00
Cefoperazone DB01329 DrugBank 5.1.4 Q9X6W0 Penicillin-binding protein 1B 99.9 774 0.0e+00
Cefpiramide DB00430 DrugBank 5.1.4 Q9X6W0 Penicillin-binding protein 1B 99.9 774 0.0e+00
Ceftazidime DB00438 DrugBank 5.1.4 Q9X6W0 Penicillin-binding protein 1B 99.9 774 0.0e+00

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004349 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2G_05253

Human Homologs

References

No references are associated with this feature.