Pseudomonas aeruginosa LESlike4, T226_RS53710

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa LESlike4
GCF_000583995.1|latest
Locus Tag
T226_RS53710
Name
Synonym: T226_23140
Replicon chromosome
Genomic location 4932259 - 4932897 (- strand)

Cross-References

RefSeq WP_003120774.1
GI 489211991

Product

Feature Type CDS
Coding Frame 1
Product Name
FMN-dependent NADH-azoreductase
Synonyms
Evidence for Translation
Charge (pH 7) -1.83
Kyte-Doolittle Hydrophobicity Value -0.075
Molecular Weight (kDa) 23.0
Isoelectric Point (pI) 6.36

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3KEG OXIDOREDUCTASE 10/26/09 X-ray Crystallographic Structure of a Y131F mutant of Pseudomonas Aeruginosa Azoreductase in complex with Methyl RED Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 99.1
2V9C OXIDOREDUCTASE 08/23/07 X-ray Crystallographic Structure of a Pseudomonas aeruginosa Azoreductase in Complex with Methyl Red. PSEUDOMONAS AERUGINOSA 2.18 X-RAY DIFFRACTION 99.5
4N9Q OXIDOREDUCTASE 10/21/13 Crystal structure of paAzoR1 bound to ubiquinone-1 Pseudomonas aeruginosa 2 X-RAY DIFFRACTION 99.5
3R6W OXIDOREDUCTASE 03/22/11 paAzoR1 binding to nitrofurazone Pseudomonas aeruginosa 2.085 X-RAY DIFFRACTION 99.5
4N65 OXIDOREDUCTASE 10/11/13 Crystal structure of paAzoR1 bound to anthraquinone-2-sulphonate Pseudomonas aeruginosa 1.816 X-RAY DIFFRACTION 99.5
3LT5 OXIDOREDUCTASE 02/15/10 X-ray Crystallographic structure of a Pseudomonas Aeruginosa Azoreductase in complex with balsalazide Pseudomonas aeruginosa 2.3 X-RAY DIFFRACTION 99.5

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
2-(4-DIMETHYLAMINOPHENYL)DIAZENYLBENZOIC ACID DB08209 DrugBank 5.1.4 Q9I5F3 FMN-dependent NADH-azoreductase 1 99.5 212 5.0e-113

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000759 (393 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: T226_RS53710

Human Homologs

References

No references are associated with this feature.