Pseudomonas aeruginosa LESB58, PALES_50851 (mrcB)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa LESB58
GCF_000026645.1|latest |
| Locus Tag |
PALES_50851
|
| Name |
mrcB
|
| Replicon | chromosome |
| Genomic location | 5611791 - 5614115 (- strand) |
Cross-References
| RefSeq | YP_002442664 |
| GI | 218893795 |
| Entrez | 7178940 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
penicillin-binding protein 1B
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | 11.89 |
| Kyte-Doolittle Hydrophobicity Value | -0.291 |
| Molecular Weight (kDa) | 85.5 |
| Isoelectric Point (pI) | 9.57 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Drugs Targeting this Protein
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
| Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
| Cefoperazone | DB01329 | DrugBank | 5.1.4 | Q9X6W0 | Penicillin-binding protein 1B | 99.9 | 774 | 0.0e+00 |
| Ceftazidime | DB00438 | DrugBank | 5.1.4 | Q9X6W0 | Penicillin-binding protein 1B | 99.9 | 774 | 0.0e+00 |
| Cefpiramide | DB00430 | DrugBank | 5.1.4 | Q9X6W0 | Penicillin-binding protein 1B | 99.9 | 774 | 0.0e+00 |
| Ceftolozane | DB09050 | DrugBank | 5.1.4 | Q9X6W0 | Penicillin-binding protein 1B | 99.9 | 774 | 0.0e+00 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 553 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG004349 (535 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PALES_50851
Search term: mrcB
Search term: penicillin-binding protein 1B
|
Human Homologs
References
No references are associated with this feature.