Pseudomonas aeruginosa AZPAE14842, NR60_RS30830

Gene Feature Overview

Strain	Pseudomonas aeruginosa AZPAE14842 GCF_000789625.1|latest
Locus Tag	NR60_RS30830
Name
Replicon	contig_45
Genomic location	41861 - 45001 (+ strand)

Cross-References

RefSeq	WP_003084631.1
GI	489175103
INSDC	BAP19568.1
NCBI Locus Tag	NR60_RS30830
UniParc	UPI0001E9E5D2
UniProtKB Acc	A0A077JKW7
UniProtKB ID	A0A077JKW7_PSEAI
UniRef100	UniRef100_A0A077JKW7
UniRef50	UniRef50_P52002
UniRef90	UniRef90_P52002

Product

Feature Type	CDS
Coding Frame	1
Product Name	multidrug transporter
Synonyms
Evidence for Translation
Charge (pH 7)	-11.88
Kyte-Doolittle Hydrophobicity Value	0.266
Molecular Weight (kDa)	112.9
Isoelectric Point (pI)	5.22

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name	Definition	Accession	Model Type (?)	SNP	Cutoff	Bit Score	Percent Identity	CARD Version
MexB	MexB is the inner membrane multidrug exporter of the efflux complex MexAB-OprM. [PMID:19361527, PMID:21178960, PMID:14973037, PMID:20583998]	ARO:3000378	protein homolog model		Strict	1978.0	99.62	3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
6IOL	MEMBRANE PROTEIN	10/30/18	Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state)	Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1	3.76	ELECTRON MICROSCOPY	99.7
3W9I	MEMBRANE PROTEIN	04/04/13	Structural basis for the inhibition of bacterial multidrug exporters	Pseudomonas aeruginosa	2.71	X-RAY DIFFRACTION	99.7
2V50	MEMBRANE PROTEIN	10/01/08	The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB	PSEUDOMONAS AERUGINOSA PA01	3	X-RAY DIFFRACTION	99.9
6IIA	MEMBRANE PROTEIN	10/04/18	MexB in complex with LMNG	Pseudomonas aeruginosa PAO1	2.91	X-RAY DIFFRACTION	99.9
3W9J	MEMBRANE PROTEIN	04/04/13	Structural basis for the inhibition of bacterial multidrug exporters	Pseudomonas aeruginosa	3.15	X-RAY DIFFRACTION	99.9
6IOK	MEMBRANE PROTEIN	10/30/18	Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state)	Pseudomonas aeruginosa PAO1	3.64	ELECTRON MICROSCOPY	99.7

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000417 (2093 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: NR60_RS30830 Search term: multidrug transporter

Human Homologs

References