Pseudomonas savastanoi pv. phaseolicola 1448A, PSPPH_4420 (adcA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas savastanoi pv. phaseolicola 1448A
GCF_000012205.1|latest
Locus Tag
PSPPH_4420
Name
adcA
Synonym: gcbA
Replicon chromosome
Genomic location 5045200 - 5046855 (- strand)

Cross-References

RefSeq YP_276536.1
GI 71737352
Entrez 3559755
INSDC AAZ37116.1
NCBI Locus Tag PSPPH_4420
UniParc UPI0000575F8B
UniProtKB Acc Q48DK5
UniProtKB ID Q48DK5_PSE14
UniRef100 UniRef100_Q48DK5
UniRef50 UniRef50_G8Q613
UniRef90 UniRef90_Q48DK5

Product

Feature Type CDS
Coding Frame 1
Product Name
AmrZ dependent cyclase A, AdcA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -5.62
Kyte-Doolittle Hydrophobicity Value -0.280
Molecular Weight (kDa) 62.1
Isoelectric Point (pI) 6.55

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 613 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004473 (530 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PSPPH_4420
Search term: adcA

Human Homologs

References

ChIP-Seq and RNA-Seq reveal an AmrZ-mediated mechanism for cyclic di-GMP synthesis and biofilm development by Pseudomonas aeruginosa.
Jones CJ, Newsom D, Kelly B, Irie Y, Jennings LK, Xu B, Limoli DH, Harrison JJ, Parsek MR, White P, Wozniak DJ
PLoS Pathog 2014 Mar;10(3):e1003984
PubMed ID: 24603766