Pseudomonas aeruginosa B136-33, G655_07100

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa B136-33
GCF_000359505.1|latest
Locus Tag
G655_07100
Name
Replicon chromosome
Genomic location 1533974 - 1535284 (- strand)

Cross-References

RefSeq YP_007708269.1
GI 478477618
Entrez 15134334
NCBI Locus Tag G655_07100

Product

Feature Type CDS
Coding Frame 1
Product Name
GDP-mannose 6-dehydrogenase
Synonyms
Evidence for Translation
Charge (pH 7) -9.09
Kyte-Doolittle Hydrophobicity Value -0.051
Molecular Weight (kDa) 47.6
Isoelectric Point (pI) 5.35

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1MFZ OXIDOREDUCTASE 08/14/02 Partially refined 2.8 A Crystal structure of GDP-mannose dehydrogenase from P. aeruginosa Pseudomonas aeruginosa 2.8 X-RAY DIFFRACTION 100.0
1MUU OXIDOREDUCTASE 09/24/02 2.0 A crystal structure of GDP-mannose dehydrogenase Pseudomonas aeruginosa 2.02 X-RAY DIFFRACTION 100.0
1MV8 OXIDOREDUCTASE 09/24/02 1.55 A crystal structure of a ternary complex of GDP-mannose dehydrogenase from Psuedomonas aeruginosa Pseudomonas aeruginosa 1.55 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Guanosine 5'-(Trihydrogen Diphosphate), P'-D-Mannopyranosyl Ester DB04023 DrugBank 5.1.4 P11759 GDP-mannose 6-dehydrogenase 100.0 436 7.2e-252
Sucrose DB02772 DrugBank 5.1.4 P11759 GDP-mannose 6-dehydrogenase 100.0 436 7.2e-252

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 588 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002126 (490 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: G655_07100

Human Homologs

References

No references are associated with this feature.