Pseudomonas aeruginosa AZPAE12153, NQ14_RS22535
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa AZPAE12153
GCF_000796925.1|latest |
| Locus Tag |
NQ14_RS22535
|
| Name |
|
| Replicon | contig_20 |
| Genomic location | 41483 - 42115 (+ strand) |
Cross-References
| RefSeq | WP_034032911.1 |
| GI | 730511193 |
| NCBI Locus Tag | NQ14_RS22535 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
TetR family transcriptional regulator
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | 0.06 |
| Kyte-Doolittle Hydrophobicity Value | -0.344 |
| Molecular Weight (kDa) | 23.8 |
| Isoelectric Point (pI) | 7.06 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AMR gene predictions from CARD database
Identified using the Resistance Gene Identifier (RGI)
| Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
| MexZ | MexZ is a transcriptional regulator that downregulates the mexXY multidrug transporter operon, which confers to aminoglycoside resistance on Pseudomonas aeruginosa. [PMID:15336398] | ARO:3003709 | protein overexpression model | Strict | 418.3 | 99.52 | 3.2.5 |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 2WUI | TRANSCRIPTION | 10/05/09 | Crystal Structure of MexZ, a key repressor responsible for antibiotic resistance in Pseudomonas aeruginosa. | PSEUDOMONAS AERUGINOSA | 2.9 | X-RAY DIFFRACTION | 99.5 |
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG003420 (237 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: NQ14_RS22535
Search term: TetR family transcriptional regulator
|
Human Homologs
References
No references are associated with this feature.