Pseudomonas aeruginosa M18, PAM18_3024
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa M18
GCF_000226155.1|latest |
| Locus Tag |
PAM18_3024
|
| Name |
|
| Replicon | chromosome |
| Genomic location | 3372344 - 3372976 (- strand) |
Cross-References
| RefSeq | YP_005975609.1 |
| GI | 386059087 |
| Entrez | 12567074 |
| NCBI Locus Tag | PAM18_3024 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
putative transcriptional regulator
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | 0.06 |
| Kyte-Doolittle Hydrophobicity Value | -0.350 |
| Molecular Weight (kDa) | 23.7 |
| Isoelectric Point (pI) | 7.06 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AMR gene predictions from CARD database
Identified using the Resistance Gene Identifier (RGI)
| Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
| MexZ | MexZ is a transcriptional regulator that downregulates the mexXY multidrug transporter operon, which confers to aminoglycoside resistance on Pseudomonas aeruginosa. [PMID:15336398] | ARO:3003709 | protein overexpression model | Strict | 420.2 | 100.0 | 3.2.5 |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 2WUI | TRANSCRIPTION | 10/05/09 | Crystal Structure of MexZ, a key repressor responsible for antibiotic resistance in Pseudomonas aeruginosa. | PSEUDOMONAS AERUGINOSA | 2.9 | X-RAY DIFFRACTION | 100.0 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 249 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG003420 (237 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PAM18_3024
Search term: putative transcriptional regulator
|
Human Homologs
References
No references are associated with this feature.