Pseudomonas aeruginosa PA7, PSPA7_3898 (lasR)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PA7 GCF_000017205.1|latest
Locus Tag	PSPA7_3898
Name	lasR
Replicon	chromosome
Genomic location	4032701 - 4033420 (- strand)

Cross-References

RefSeq	YP_001349253.1
GI	152989200
Entrez	5358388
INSDC	ABR86383.1
NCBI Locus Tag	PSPA7_3898
UniParc	UPI0001577429
UniProtKB Acc	A6V868
UniProtKB ID	A6V868_PSEA7
UniRef100	UniRef100_A6V868
UniRef50	UniRef50_P25084
UniRef90	UniRef90_P25084

Product

Feature Type	CDS
Coding Frame	1
Product Name	transcriptional regulator LasR
Synonyms
Evidence for Translation
Charge (pH 7)	-1.68
Kyte-Doolittle Hydrophobicity Value	-0.017
Molecular Weight (kDa)	26590.3
Isoelectric Point (pI)	6.51

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
6MWW	TRANSCRIPTION	10/30/18	LasR LBD:BB0126 complex	Pseudomonas aeruginosa (strain UCBPP-PA14)	2.76	X-RAY DIFFRACTION	98.7
3IX8	TRANSCRIPTION	09/03/09	LasR-TP3 complex	Pseudomonas aeruginosa	1.8	X-RAY DIFFRACTION	98.3
6V7X	DNA BINDING PROTEIN/Viral protein	12/09/19	Structure of a phage-encoded quorum sensing anti-activator, Aqs1 bound to LasR	Pseudomonas aeruginosa (strain UCBPP-PA14); Pseudomonas virus DMS3	2.9	X-RAY DIFFRACTION	98.7
2UV0	TRANSCRIPTION	03/08/07	Structure of the P. aeruginosa LasR ligand-binding domain bound to its autoinducer	PSEUDOMONAS AERUGINOSA	1.8	X-RAY DIFFRACTION	98.3
3IX4	TRANSCRIPTION	09/03/09	LasR-TP1 complex	Pseudomonas aeruginosa	1.8	X-RAY DIFFRACTION	98.3
6V7W	DNA BINDING PROTEIN/Viral protein	12/09/19	Crystal structure of LasR-Aqs1 complex from Pseudomonas aeruginosa	Pseudomonas aeruginosa (strain UCBPP-PA14); Pseudomonas virus DMS3	3	X-RAY DIFFRACTION	98.7
6MWH	TRANSCRIPTION	10/29/18	LasR LBD:BB0020 complex	Pseudomonas aeruginosa (strain UCBPP-PA14)	2.2	X-RAY DIFFRACTION	98.7
3JPU	TRANSCRIPTION	09/04/09	LasR-TP4 complex	Pseudomonas aeruginosa	2.3	X-RAY DIFFRACTION	98.3
6MVN	TRANSCRIPTION	10/26/18	LasR LBD L130F:3OC10HSL complex	Pseudomonas aeruginosa (strain UCBPP-PA14)	2.2	X-RAY DIFFRACTION	98.3
6MWZ	TRANSCRIPTION	10/30/18	LasR LBD T75V/Y93F/A127W:BB0126	Pseudomonas aeruginosa (strain UCBPP-PA14); Pseudomonas aeruginosa UCBPP-PA14	1.657	X-RAY DIFFRACTION	97.5
3IX3	TRANSCRIPTION	09/03/09	LasR-OC12 HSL complex	Pseudomonas aeruginosa	1.4	X-RAY DIFFRACTION	98.3
6MWL	TRANSCRIPTION	10/29/18	LasR LBD:mBTL complex	Pseudomonas aeruginosa (strain UCBPP-PA14)	1.5	X-RAY DIFFRACTION	98.7

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 144 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG001096 (1439 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PSPA7_3898 Search term: lasR Search term: transcriptional regulator LasR

Human Homologs

References