Pseudomonas aeruginosa PA7, PSPA7_1961 (gyrA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa PA7
GCF_000017205.1|latest
Locus Tag
PSPA7_1961
Name
gyrA
Replicon chromosome
Genomic location 1991539 - 1994304 (+ strand)

Cross-References

RefSeq YP_001347342.1
GI 152985032
EC Number 5.99.1.3
Entrez 5355666
INSDC ABR82215.1
NCBI Locus Tag PSPA7_1961
UniParc UPI0000D7352D
UniProtKB Acc A6V2Q7
UniProtKB ID A6V2Q7_PSEA7
UniRef100 UniRef100_W0YVD3
UniRef50 UniRef50_P0AES4
UniRef90 UniRef90_S6AY64

Product

Feature Type CDS
Coding Frame 1
Product Name
DNA gyrase subunit A
Synonyms
Evidence for Translation
Charge (pH 7) -39.06
Kyte-Doolittle Hydrophobicity Value -0.238
Molecular Weight (kDa) 101.0
Isoelectric Point (pI) 4.63

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
Pseudomonas aeruginosa gyrA conferring resistance to fluoroquinolones Point mutation of Pseudomonas aeruginosa gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance. [PMID:22821356, PMID:8540700] ARO:3003684 protein variant model T83I Strict 1736.1 99.13 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 631 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002447 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PSPA7_1961
Search term: gyrA

Human Homologs

References

No references are associated with this feature.