Pseudomonas aeruginosa PA7, PSPA7_1605 (algD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa PA7
GCF_000017205.1|latest
Locus Tag
PSPA7_1605
Name
algD
Replicon chromosome
Genomic location 1638550 - 1639869 (- strand)

Cross-References

RefSeq YP_001346989.1
GI 152989456
Entrez 5357214
NCBI Locus Tag PSPA7_1605

Product

Feature Type CDS
Coding Frame 1
Product Name
GDP-mannose 6-dehydrogenase AlgD
Synonyms
Evidence for Translation
Charge (pH 7) -9.09
Kyte-Doolittle Hydrophobicity Value -0.049
Molecular Weight (kDa) 47915.5
Isoelectric Point (pI) 5.35

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1MV8 OXIDOREDUCTASE 09/24/02 1.55 A crystal structure of a ternary complex of GDP-mannose dehydrogenase from Psuedomonas aeruginosa Pseudomonas aeruginosa 1.55 X-RAY DIFFRACTION 99.8
1MFZ OXIDOREDUCTASE 08/14/02 Partially refined 2.8 A Crystal structure of GDP-mannose dehydrogenase from P. aeruginosa Pseudomonas aeruginosa 2.8 X-RAY DIFFRACTION 99.8
1MUU OXIDOREDUCTASE 09/24/02 2.0 A crystal structure of GDP-mannose dehydrogenase Pseudomonas aeruginosa 2.02 X-RAY DIFFRACTION 99.8

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Sucrose DB02772 DrugBank 5.1.4 P11759 GDP-mannose 6-dehydrogenase 99.8 436 1.2e-251
Guanosine 5'-(Trihydrogen Diphosphate), P'-D-Mannopyranosyl Ester DB04023 DrugBank 5.1.4 P11759 GDP-mannose 6-dehydrogenase 99.8 436 1.2e-251

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 588 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002126 (490 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PSPA7_1605
Search term: algD

Human Homologs

References

No references are associated with this feature.