Pseudomonas aeruginosa UCBPP-PA14, PA14_66670 (ponA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_66670
Name
ponA
Replicon chromosome
Genomic location 5952288 - 5954759 (+ strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 4 transposon mutants in orthologs

Cross-References

RefSeq YP_793514.1
GI 116053193
Entrez 4385528
INSDC ABJ14429.1
NCBI Locus Tag PA14_66670
UniParc UPI000045D4FE
UniProtKB Acc Q02EX2
UniProtKB ID Q02EX2_PSEAB
UniRef100 UniRef100_Q02EX2
UniRef50 UniRef50_Q07806
UniRef90 UniRef90_Q07806

Product

Feature Type CDS
Coding Frame 1
Product Name
penicillin-binding protein 1A
Synonyms
Evidence for Translation
Charge (pH 7) -4.09
Kyte-Doolittle Hydrophobicity Value -0.348
Molecular Weight (kDa) 91.3
Isoelectric Point (pI) 6.19

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4OON transferase/transferase inhibitor 02/03/14 Crystal structure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) Pseudomonas aeruginosa PAO1 3.2 X-RAY DIFFRACTION 99.2

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 555 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004648 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_66670
Search term: ponA

Human Homologs

References

No references are associated with this feature.